Voluhemins, new inhibitors of sterol O-acyltransferase, produced by Volutella citrinella BF-0440.
Journal
The Journal of antibiotics
ISSN: 1881-1469
Titre abrégé: J Antibiot (Tokyo)
Pays: England
ID NLM: 0151115
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
07
03
2020
accepted:
07
05
2020
revised:
13
04
2020
pubmed:
30
5
2020
medline:
20
2
2021
entrez:
30
5
2020
Statut:
ppublish
Résumé
New compounds, designated voluhemins A (1) and B (2), are isolated from the culture broth of the fungal strain Volutella citrinella BF-0440 along with structurally related known NK12838 (3). Spectroscopic data, including 1D and 2D NMR, elucidated their structures. Compounds 1-3 have a common indoline-diterpene core and two additional isoprenyl moieties. Compounds 1 and 3 contain a hemiaminal unit, while 2 is O-methylated 1. Their inhibitory activities toward sterol O-acyltransferase (SOAT) 1 and 2 isozymes in SOAT1- and SOAT2-expressing Chinese hamster ovary (CHO) cells show that 2 selectively inhibits the SOAT2 isozyme.
Identifiants
pubmed: 32467602
doi: 10.1038/s41429-020-0327-0
pii: 10.1038/s41429-020-0327-0
doi:
Substances chimiques
Enzyme Inhibitors
0
Sterol O-Acyltransferase
EC 2.3.1.26
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
748-755Références
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