Liver Fibrosis and Inflammation under the Control of ERK2.
ERK2
MAPK
liver cirrhosis
liver inflammation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 May 2020
27 May 2020
Historique:
received:
15
04
2020
revised:
19
05
2020
accepted:
25
05
2020
entrez:
31
5
2020
pubmed:
31
5
2020
medline:
17
2
2021
Statut:
epublish
Résumé
Chronic liver injury could lead the formation of liver fibrosis, eventually some would develop to hepatocellular carcinoma (HCC), one of the leading malignancies worldwide. The aim of the study is to dissect the role of extracellular signal-regulated kinase 2 (ERK2) signaling in liver fibrosis and inflammation. The choline-deficient, ethionine-supplemented (CDE) diet could lead to fatty livers and generate oval cells, activate hepatocyte stellate cell (HSC) and recruit immune cells as the liver fibrosis model mice. WT and ERK2 deficient (ERK2
Identifiants
pubmed: 32471201
pii: ijms21113796
doi: 10.3390/ijms21113796
pmc: PMC7312875
pii:
doi:
Substances chimiques
Actins
0
Forkhead Box Protein M1
0
Foxm1 protein, mouse
0
alpha-smooth muscle actin, mouse
0
Mapk1 protein, mouse
EC 2.7.11.24
Mitogen-Activated Protein Kinase 1
EC 2.7.11.24
Matrix Metalloproteinase 9
EC 3.4.24.35
Mmp9 protein, mouse
EC 3.4.24.35
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : the Ministry of Science and Technology, Taiwan
ID : MOST 106-2314-B-418-001-MY3, MOST 105-2320-B418-001, MOST 104-2314-B-418-018
Organisme : Far Eastern Memorial Hospital
ID : FEMH-106-2314-B-418-001-MY3, FEMH-2019-C-078, FEMH-2020-C-092
Organisme : Far Eastern Memorial Hospital-National Yang-Ming University Joint Research Program
ID : 107DN17, 108DN28, 109DN28
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