Current and Future Prospective of a Versatile Moiety: Imidazole.
14α-demethylase
Azole heterocycle
cytochrome P450
enzyme
imidazole
marketed imidazole drug
Journal
Current drug targets
ISSN: 1873-5592
Titre abrégé: Curr Drug Targets
Pays: United Arab Emirates
ID NLM: 100960531
Informations de publication
Date de publication:
2020
2020
Historique:
received:
26
11
2019
revised:
11
02
2020
accepted:
19
03
2020
pubmed:
31
5
2020
medline:
25
6
2021
entrez:
31
5
2020
Statut:
ppublish
Résumé
Imidazole containing compounds have been a very much explored field since ancient times. Subsequently, it constitutes a significant moiety for the new drug development. A variety of compounds having imidazole moiety have been synthesized, evaluated and marketed for the treatment of various diseases such as antifungal, antiepileptic, ACE inhibitors and so on, as shown in the figure. The search for imidazole containing compounds with more selective biological potency with low side effects continues to be an active area of research in medicinal chemistry. This review is in an effort to highlight the marketed drugs with imidazole ring. The article also demonstrates the future prospective of marketed imidazoles as antifungal with potential activity targeting 14α-demethylase enzyme.
Identifiants
pubmed: 32472996
pii: CDT-EPUB-106986
doi: 10.2174/1389450121666200530203247
doi:
Substances chimiques
14-alpha Demethylase Inhibitors
0
Antifungal Agents
0
Imidazoles
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1130-1155Informations de copyright
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