Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus.
Animals
Apoptosis
Caspases
/ metabolism
Cell Death
Cell Line
Disease Models, Animal
Female
Granzymes
/ chemistry
Herpesviridae Infections
/ immunology
Mice
Mice, Inbred C57BL
Mice, Knockout
Mitochondria
/ metabolism
Muromegalovirus
/ immunology
Peptides
/ immunology
Proto-Oncogene Proteins c-bcl-2
/ metabolism
Substrate Specificity
T-Lymphocytes, Cytotoxic
/ immunology
Viral Proteins
/ immunology
bcl-X Protein
/ metabolism
Cytotoxic T lymphocyte
Granzyme B
Mouse cytomegalovirus
Perforin
Proteolysis
TAILS
Journal
Biochimica et biophysica acta. Proteins and proteomics
ISSN: 1878-1454
Titre abrégé: Biochim Biophys Acta Proteins Proteom
Pays: Netherlands
ID NLM: 101731734
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
15
01
2020
revised:
11
05
2020
accepted:
21
05
2020
pubmed:
31
5
2020
medline:
27
10
2020
entrez:
31
5
2020
Statut:
ppublish
Résumé
We investigated the molecular basis for the remarkably different survival outcomes of mice expressing different alloforms of the pro-apoptotic serine protease granzyme B to mouse cytomegalovirus infection. Whereas C57BL/6 mice homozygous for granzyme B
Identifiants
pubmed: 32473350
pii: S1570-9639(20)30104-7
doi: 10.1016/j.bbapap.2020.140457
pii:
doi:
Substances chimiques
Bcl2l1 protein, mouse
0
Peptides
0
Proto-Oncogene Proteins c-bcl-2
0
Viral Proteins
0
bcl-X Protein
0
Bcl2 protein, mouse
114100-40-2
Granzymes
EC 3.4.21.-
Gzmb protein, mouse
EC 3.4.21.-
Caspases
EC 3.4.22.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
140457Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.