Environmental enrichment modulates affiliative and aggressive social behaviour in the neuroligin-3 R451C mouse model of autism spectrum disorder.
Aggression
/ psychology
Animals
Anxiety
Autism Spectrum Disorder
/ psychology
Behavior, Animal
Body Weight
Cell Adhesion Molecules, Neuronal
/ genetics
Disease Models, Animal
Female
Housing, Animal
Locomotion
Male
Maze Learning
Membrane Proteins
/ genetics
Mice
Mice, Inbred C57BL
Mutation
Nerve Tissue Proteins
/ genetics
Physical Conditioning, Animal
/ psychology
Social Interaction
Aggression
Autism spectrum disorder
Environmental enrichment
Neuroligin-3
R451C
Social interaction
Journal
Pharmacology, biochemistry, and behavior
ISSN: 1873-5177
Titre abrégé: Pharmacol Biochem Behav
Pays: United States
ID NLM: 0367050
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
08
01
2020
revised:
20
05
2020
accepted:
26
05
2020
pubmed:
1
6
2020
medline:
9
2
2021
entrez:
1
6
2020
Statut:
ppublish
Résumé
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by impairments in social communication and the presence of restrictive and repetitive behaviours. A mouse model expressing an autism-associated R451C mutation in the gene encoding the synaptic adhesion protein neuroligin-3 (NL3) has been extensively characterised and shows altered behaviour relevant to core traits observed in ASD. Reported impairments in social behaviours in NL3
Identifiants
pubmed: 32474162
pii: S0091-3057(20)30014-9
doi: 10.1016/j.pbb.2020.172955
pii:
doi:
Substances chimiques
Cell Adhesion Molecules, Neuronal
0
Membrane Proteins
0
Nerve Tissue Proteins
0
neuroligin 3
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
172955Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.