Berberine-induced nucleolar stress response in a human breast cancer cell line.
Apoptosis
/ drug effects
Berberine
/ pharmacology
Breast Neoplasms
/ pathology
Cell Cycle Checkpoints
/ drug effects
Cell Line, Tumor
Cell Nucleolus
/ drug effects
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Cyclin-Dependent Kinase Inhibitor p21
/ metabolism
Female
Fluorescence
Humans
Ribosomal Proteins
/ metabolism
Stress, Physiological
/ drug effects
Tumor Suppressor Protein p53
/ metabolism
Berberine
Intracellular distribution
MCF12A
MCF7
Nucleolar stress
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
12 07 2020
12 07 2020
Historique:
received:
22
04
2020
accepted:
04
05
2020
pubmed:
2
6
2020
medline:
14
1
2021
entrez:
2
6
2020
Statut:
ppublish
Résumé
We investigated the novel molecular mechanisms of the antitumor effect of berberine. In this study, two different human cell lines (breast cancer MCF7 cells and non-tumorigenic epithelial MCF12A cells) were treated with various concentrations of berberine. Treatment with 1 and 10 μM berberine inhibited proliferation with G
Identifiants
pubmed: 32475643
pii: S0006-291X(20)30926-8
doi: 10.1016/j.bbrc.2020.05.020
pii:
doi:
Substances chimiques
Cyclin-Dependent Kinase Inhibitor p21
0
Ribosomal Proteins
0
Tumor Suppressor Protein p53
0
ribosomal protein L5
0
Berberine
0I8Y3P32UF
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
227-233Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest There are no conflicts of interest to declare.