IgG4-related Autoimmune Hepatitis with a Suspected Drug-induced Etiology.
Aged
Anti-Inflammatory Agents
/ therapeutic use
Cholagogues and Choleretics
/ therapeutic use
Hepatitis, Autoimmune
/ diagnosis
Hepatitis, Chronic
/ drug therapy
Humans
Immunoglobulin G
/ blood
Japan
Male
Nifedipine
/ adverse effects
Prednisolone
/ therapeutic use
Treatment Outcome
Ursodeoxycholic Acid
/ therapeutic use
IgG4
autoimmune hepatitis
drug-induced
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
2
6
2020
pubmed:
2
6
2020
medline:
25
8
2020
Statut:
ppublish
Résumé
A 69-year-old man was referred to our department with acute hepatitis. He had been newly treated with benidipine hydrochloride for two months. His blood test results were as follows: aspartate aminotransferase, 1,614 IU/L; alanine aminotransferase, 1,091 IU/L and anti-smooth muscle antibody, ×80. Needle liver biopsy specimen showed interface hepatitis with mainly lymphocytic infiltration and bridging fibrosis in the periportal area. Immunohistochemistry revealed lymphocytic infiltration positive for IgG4. We diagnosed him with IgG4-related AIH with an etiology that was suspected of being drug-induced. Oral prednisolone was started and then tapered after achieving biochemical remission. Hepatitis recurred after the cessation of steroids; however, remission was achieved with ursodeoxycholic acid.
Identifiants
pubmed: 32475907
doi: 10.2169/internalmedicine.4092-19
pmc: PMC7332635
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Cholagogues and Choleretics
0
Immunoglobulin G
0
Ursodeoxycholic Acid
724L30Y2QR
Prednisolone
9PHQ9Y1OLM
Nifedipine
I9ZF7L6G2L
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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