Evidence for misleading decision support in characterizing differences in tolerance to reduced central blood volume using measurements of tissue oxygenation.
Journal
Transfusion
ISSN: 1537-2995
Titre abrégé: Transfusion
Pays: United States
ID NLM: 0417360
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
23
09
2019
revised:
09
12
2019
accepted:
09
12
2019
pubmed:
2
6
2020
medline:
17
7
2021
entrez:
2
6
2020
Statut:
ppublish
Résumé
The physiological response to hemorrhage includes vasoconstriction in an effort to shunt blood to the heart and brain. Hemorrhaging patients can be classified as "good" compensators who demonstrate high tolerance (HT) or "poor" compensators who manifest low tolerance (LT) to central hypovolemia. Compensatory vasoconstriction is manifested by lower tissue oxygen saturation (StO Fifty-one healthy volunteers (37% LT) were subjected to progressive lower body negative pressure (LBNP) as a model of controlled hemorrhage designed to induce an onset of decompensation. During LBNP, CRM was determined by arterial waveform feature analysis. StO These values were statistically indistinguishable between HT and LT participants at baseline (p ≥ 0.25). HT participants exhibited lower (p = 0.01) StO Lower StO
Sections du résumé
BACKGROUND
The physiological response to hemorrhage includes vasoconstriction in an effort to shunt blood to the heart and brain. Hemorrhaging patients can be classified as "good" compensators who demonstrate high tolerance (HT) or "poor" compensators who manifest low tolerance (LT) to central hypovolemia. Compensatory vasoconstriction is manifested by lower tissue oxygen saturation (StO
METHODS
Fifty-one healthy volunteers (37% LT) were subjected to progressive lower body negative pressure (LBNP) as a model of controlled hemorrhage designed to induce an onset of decompensation. During LBNP, CRM was determined by arterial waveform feature analysis. StO
RESULTS
These values were statistically indistinguishable between HT and LT participants at baseline (p ≥ 0.25). HT participants exhibited lower (p = 0.01) StO
CONCLUSIONS
Lower StO
Substances chimiques
Hemoglobins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
S62-S69Subventions
Organisme : US Army Research and Development Command
ID : D-0010-2001-IS; E52-0019-2005; E52-0015-2005; D-02
Organisme : US Army Medical Research and Development Command Combat Casualty Care Research Program
ID : D-009-2014-USAISR
Organisme : US Army Medical Research and Development Command Combat Casualty Care Research Program
ID : D-023-2011-USAISR
Organisme : US Army Medical Research and Development Command Combat Casualty Care Research Program
ID : E52-0015-2005
Organisme : US Army Medical Research and Development Command Combat Casualty Care Research Program
ID : E52-0019-2005
Organisme : US Army Medical Research and Development Command Combat Casualty Care Research Program
ID : D-0010-2001-IS
Informations de copyright
Published 2020. This article is a U.S. Government work and is in the public domain in the USA.
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