Tumour necrosis factor-α and myoglobin associated with the recovery time of coronary artery lesions in Kawasaki disease patients.
Kawasaki disease
coronary artery lesion
myoglobin
tumour necrosis factor-α
Journal
Journal of paediatrics and child health
ISSN: 1440-1754
Titre abrégé: J Paediatr Child Health
Pays: Australia
ID NLM: 9005421
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
14
12
2018
revised:
20
01
2020
accepted:
12
04
2020
pubmed:
2
6
2020
medline:
15
5
2021
entrez:
2
6
2020
Statut:
ppublish
Résumé
To assess the relationship between clinical parameters and medium term recovery time of coronary artery lesions (CALs). In total, 344 Kawasaki disease patients were screened and 311 Kawasaki disease patients were included and followed-up for the next 2 years. Clinical records, clinical parameters and inflammatory biomarkers were collected for all subjects. Tumour necrosis factor (TNF)-α and myoglobin (MYO) levels in patients without recovery from CALs were significantly higher than those without CALs and with recovery from CALs. Kaplan-Meier survival analysis showed that in the high-TNF-α group, the estimated median time to recovery (5.0 months, 95% confidence interval (CI) 1.436-8.564) is significantly longer than the low-TNF-α group (2.00 months, 95% CI: 0.633-3.367, P = 0.044). Also, the estimated median time (5.0 months, 95% CI: 1.836-8.164) in the high-MYO group is significantly longer than the low-MYO group (2.00 months, 95% CI: 0.405-3.595, P = 0.002). Cox regression analysis showed independent factors for recovery of CALs included age, left coronary artery to aortic annulus ratio, TNF-α and MYO levels. These findings suggest that clinical parameters such as age, left coronary artery to aortic annulus ratio, TNF-α and MYO levels associate with medium term recovery time of CALs and could help in the design of a clinical strategy for the surveillance and prevention of late cardiovascular events.
Substances chimiques
Myoglobin
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1382-1387Subventions
Organisme : China National Natural Science Fund
ID : 81600502
Organisme : Clinical Guidance Project of Hunan Provincial Science and Technology Department
ID : 2017SK50502
Organisme : The Young Doctor Training Program
ID : BSJJ201801
Informations de copyright
© 2020 Paediatrics and Child Health Division (The Royal Australasian College of Physicians).
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