Spectrofluorimetric approach for determination of tranexamic acid in pure form and pharmaceutical formulations; Application in human plasma.
Human plasma
NBD-CL
Spectrofluorimetry
Tranexamic acid
Journal
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
ISSN: 1873-3557
Titre abrégé: Spectrochim Acta A Mol Biomol Spectrosc
Pays: England
ID NLM: 9602533
Informations de publication
Date de publication:
05 Oct 2020
05 Oct 2020
Historique:
received:
23
04
2020
revised:
14
05
2020
accepted:
18
05
2020
pubmed:
2
6
2020
medline:
15
5
2021
entrez:
2
6
2020
Statut:
ppublish
Résumé
Tranexamic acid (TXA) is an important antihemorrhagic drug that needs a simple, sensitive and low cost spectrofluorimetric method for its determination. This method depends on generation of a yellow product which produced from a nucleophilic substitution reaction of the lone pair of electrons on the amino group found in the TXA chemical structure and 4-chloro-7-nitrobenzofurazan (NBD-Cl) in borate buffer PH 9.0. The product was measured at 536 nm (λex = 470.5 nm). All variables that have an effect on the formation and stability of the product have been explored and optimized. The linear range was 20-100 ng mL
Identifiants
pubmed: 32480274
pii: S1386-1425(20)30489-3
doi: 10.1016/j.saa.2020.118510
pii:
doi:
Substances chimiques
Tablets
0
Tranexamic Acid
6T84R30KC1
4-Chloro-7-nitrobenzofurazan
EQF2794IRE
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
118510Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.