Elevated Monocyte Count and Loss of Renal Function in Renal Transplant Patients.
Journal
Transplantation proceedings
ISSN: 1873-2623
Titre abrégé: Transplant Proc
Pays: United States
ID NLM: 0243532
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
15
01
2020
revised:
15
02
2020
accepted:
23
02
2020
pubmed:
3
6
2020
medline:
16
2
2021
entrez:
3
6
2020
Statut:
ppublish
Résumé
Rejection is an important factor affecting graft function in renal transplant patients. Development of acute rejection even after induction treatment suggests that humoral and cellular immune systems are not the only mechanisms responsible for this event. The innate immune system can play roles in rejection. The aim of this study is to evaluate the association between renal function and some absolute values and ratios of various hematologic parameters assessed before and after renal transplantation. This study included 63 renal transplant patients. Demographic features and laboratory findings were reviewed retrospectively and recorded. For cadaveric and spousal transplantations, induction treatment used antithymocyte globulin (ATG) (group 1 [G1]), and CD25 inhibitor was used for the others (group 2 [G2]). G2 was divided into 2 subgroups based on the estimated glomerular filtration rate (eGFR) decline rate: ≤ 3.5 mL/min/y as group 2a (G2a) and > 3.5 mL/min/y as group 2b (G2b). Hematologic parameters were compared across the groups. Compared to G1, G2 had higher mean blood pressure, blood urea nitrogen, creatinine, and first month post-transplant lymphocyte and monocyte counts (P = .034, P = .040, P = .003, P = .027, and P = .027, respectively). G2a had higher levels of first-month post-transplant white blood cell, monocyte, and neutrophil counts compared to G2b (P = .018, P = .038, and P = .011, respectively). Receiver operating characteristic analysis of the parameters in G2b showed that a monocyte count of > 750 mm Elevated monocyte count in patients who had faster eGFR decline and did not receive induction treatment with ATG points to the significance of the innate immune system.
Sections du résumé
BACKGROUND
BACKGROUND
Rejection is an important factor affecting graft function in renal transplant patients. Development of acute rejection even after induction treatment suggests that humoral and cellular immune systems are not the only mechanisms responsible for this event. The innate immune system can play roles in rejection. The aim of this study is to evaluate the association between renal function and some absolute values and ratios of various hematologic parameters assessed before and after renal transplantation.
METHODS
METHODS
This study included 63 renal transplant patients. Demographic features and laboratory findings were reviewed retrospectively and recorded. For cadaveric and spousal transplantations, induction treatment used antithymocyte globulin (ATG) (group 1 [G1]), and CD25 inhibitor was used for the others (group 2 [G2]). G2 was divided into 2 subgroups based on the estimated glomerular filtration rate (eGFR) decline rate: ≤ 3.5 mL/min/y as group 2a (G2a) and > 3.5 mL/min/y as group 2b (G2b). Hematologic parameters were compared across the groups.
RESULTS
RESULTS
Compared to G1, G2 had higher mean blood pressure, blood urea nitrogen, creatinine, and first month post-transplant lymphocyte and monocyte counts (P = .034, P = .040, P = .003, P = .027, and P = .027, respectively). G2a had higher levels of first-month post-transplant white blood cell, monocyte, and neutrophil counts compared to G2b (P = .018, P = .038, and P = .011, respectively). Receiver operating characteristic analysis of the parameters in G2b showed that a monocyte count of > 750 mm
CONCLUSION
CONCLUSIONS
Elevated monocyte count in patients who had faster eGFR decline and did not receive induction treatment with ATG points to the significance of the innate immune system.
Identifiants
pubmed: 32482450
pii: S0041-1345(20)30124-X
doi: 10.1016/j.transproceed.2020.02.176
pii:
doi:
Substances chimiques
Antilymphocyte Serum
0
Immunosuppressive Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3080-3084Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.