Multifunctional Core-Shell Glyconanoparticles for Galectin-3-Targeted, Trigger-Responsive Combination Chemotherapy.

Doxorubicin Drug Delivery Systems Drug Therapy, Combination Endothelial Cells Galectin 3 Hydrogen-Ion Concentration Nanoparticles Tissue Distribution

Journal

Biomacromolecules
ISSN: 1526-4602
Titre abrégé: Biomacromolecules
Pays: United States
ID NLM: 100892849

Informations de publication

Date de publication:
13 07 2020
Historique:
pubmed: 3 6 2020
medline: 22 6 2021
entrez: 3 6 2020
Statut: ppublish

Résumé

Galectin-3 (gal-3) plays a crucial role in various cellular events associated to tumor metastasis and progression. In this direction, gal-3 binding core-shell glyconanoparticles based on citrus pectin (CP) have been designed for targeted, trigger-responsive combination drug delivery. Depolymerization via periodate oxidation in heterogeneous medium yielded low-molecular weight dialdehyde oligomers (CPDA) of CP with a gal-3 binding property (

Identifiants

DOI: 10.1021/acs.biomac.0c00358 PMID: 32484667
pubmed: 32484667
doi: 10.1021/acs.biomac.0c00358
doi:

Substances chimiques

Galectin 3 0
Doxorubicin 80168379AG

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2645-2660

Auteurs

Biji Balakrishnan (B)

Nanomedicine Laboratory, Department of Biosciences and Bioengineering, IIT Bombay, Mumbai 400076, India.
ORCID: 0000-0003-2331-5032

Suresh Subramanian (S)

Radiopharmaceuticals Division, BARC, Trombay, Mumbai 400085, India.
Homi Bhabha National Institute, Mumbai 400094, India.

Madhava B Mallia (MB)

Radiopharmaceuticals Division, BARC, Trombay, Mumbai 400085, India.
Homi Bhabha National Institute, Mumbai 400094, India.

Krishnamohan Repaka (K)

Board of Radiation and Isotope Technology, Navi Mumbai 400703, India.

Shahdeep Kaur (S)

Nanomedicine Laboratory, Department of Biosciences and Bioengineering, IIT Bombay, Mumbai 400076, India.

Rajeet Chandan (R)

Nanomedicine Laboratory, Department of Biosciences and Bioengineering, IIT Bombay, Mumbai 400076, India.

Prateek Bhardwaj (P)

Nanomedicine Laboratory, Department of Biosciences and Bioengineering, IIT Bombay, Mumbai 400076, India.

Ashutosh Dash (A)

Radiopharmaceuticals Division, BARC, Trombay, Mumbai 400085, India.
Homi Bhabha National Institute, Mumbai 400094, India.

Rinti Banerjee (R)

Nanomedicine Laboratory, Department of Biosciences and Bioengineering, IIT Bombay, Mumbai 400076, India.

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Classifications MeSH

questionsmedicales.fr › Glucides › Hétérosides › Aminosides › Anthracyclines › Daunorubicine › Doxorubicine › Multifunctional Core-Shell Glyconanoparticles...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Multifunctional Core-Shell Glyconanoparticles...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Association de médicaments › Multifunctional Core-Shell Glyconanoparticles...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Multifunctional Core-Shell Glyconanoparticles...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lectines › Galectines › Galectine -3 › Multifunctional Core-Shell Glyconanoparticles...
questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › Multifunctional Core-Shell Glyconanoparticles...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Multifunctional Core-Shell Glyconanoparticles...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Multifunctional Core-Shell Glyconanoparticles...