Lactate dehydrogenase expression modulates longevity and neurodegeneration in

Animals Animals, Genetically Modified Brain / cytology Circadian Rhythm / physiology Drosophila Proteins / genetics Drosophila melanogaster / physiology Female Humans L-Lactate Dehydrogenase / genetics Lactic Acid / analysis Locomotion / physiology Longevity / physiology Male Neurons / metabolism
aging circadian rhythms lactate lactate dehydrogenase lifespan neurodegeneration

Journal

Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617

Informations de publication

Date de publication:
02 06 2020
Historique:
received: 04 04 2020
accepted: 14 05 2020
pubmed: 3 6 2020
medline: 9 3 2021
entrez: 3 6 2020
Statut: ppublish

Résumé

Lactate dehydrogenase (LDH) catalyzes the conversion of glycolysis-derived pyruvate to lactate. Lactate has been shown to play key roles in brain energetics and memory formation. However, lactate levels are elevated in aging and Alzheimer's disease patients, and it is not clear whether lactate plays protective or detrimental roles in these contexts. Here we show that

Identifiants

DOI: 10.18632/aging.103373 PMID: 32484787 PMC: PMC7346061
pubmed: 32484787
pii: 103373
doi: 10.18632/aging.103373
pmc: PMC7346061
doi:

Substances chimiques

Drosophila Proteins 0
Lactic Acid 33X04XA5AT
L-Lactate Dehydrogenase EC 1.1.1.27

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

10041-10058

Subventions

Organisme : NIA NIH HHS
ID : R21 AG055943
Pays : United States
Organisme : NIH HHS
ID : S10 OD018518
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG062621
Pays : United States
Organisme : NIH HHS
ID : P40 OD018537
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG053460
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG061406
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG052950
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG045830
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM084947
Pays : United States

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Auteurs

Dani M Long (DM)

Department of Integrative Biology, Oregon State University, Corvallis, OR 97331, USA.
Present address: Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, OR 97239, USA.

Ariel K Frame (AK)

Department of Biology, Western University of London, London N6A 5B7, Ontario, Canada.

Patrick N Reardon (PN)

OSU NMR Facility, Oregon State University, Corvallis, OR 97331, USA.

Robert C Cumming (RC)

Department of Biology, Western University of London, London N6A 5B7, Ontario, Canada.

David A Hendrix (DA)

Department of Biochemistry and Biophysics, School of Electrical Engineering and Computer Science, Corvallis, OR 97331, USA.

Doris Kretzschmar (D)

Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, OR 97239, USA.

Jadwiga M Giebultowicz (JM)

Department of Integrative Biology, Oregon State University, Corvallis, OR 97331, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Lactate dehydrogenase expression modulates...
questionsmedicales.fr › Stades d'organismes › Organismes génétiquement modifiés › Animal génétiquement modifié › Lactate dehydrogenase expression modulates...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Lactate dehydrogenase expression modulates...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes chronobiologiques › Périodicité › Rythme circadien › Lactate dehydrogenase expression modulates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'arthropode › Protéines d'insecte › Protéines de Drosophila › Lactate dehydrogenase expression modulates...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › Lactate dehydrogenase expression modulates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Lactate dehydrogenase expression modulates...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Alcohol oxidoreductases › NAD (+) and NADP (+) dependent Alcohol oxidoreductases › L-Lactate dehydrogenase › Lactate dehydrogenase expression modulates...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Lactates › Acide lactique › Lactate dehydrogenase expression modulates...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Locomotion › Lactate dehydrogenase expression modulates...
questionsmedicales.fr › Phénomènes physiologiques › Longévité › Lactate dehydrogenase expression modulates...
questionsmedicales.fr › Cellules › Neurones › Lactate dehydrogenase expression modulates...