Developmental exposure to 17α-hydroxyprogesterone caproate impairs adult delayed reinforcement and reversal learning in male and female rats.
17 alpha-Hydroxyprogesterone Caproate
/ pharmacology
Animals
Animals, Newborn
Behavior, Animal
/ drug effects
Conditioning, Operant
/ drug effects
Delay Discounting
/ drug effects
Female
Male
Pregnancy
Prenatal Exposure Delayed Effects
/ chemically induced
Rats
Rats, Long-Evans
Reinforcement, Psychology
Reversal Learning
/ drug effects
17-alpha-hydroxyprogesterone
animal behaviour
delayed reinforcement
newborn animals
operant behaviour
reversal learning
Journal
Journal of neuroendocrinology
ISSN: 1365-2826
Titre abrégé: J Neuroendocrinol
Pays: United States
ID NLM: 8913461
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
18
12
2019
revised:
25
03
2020
accepted:
06
05
2020
pubmed:
3
6
2020
medline:
21
7
2021
entrez:
3
6
2020
Statut:
ppublish
Résumé
Women with a history of unexplained miscarriage are frequently prescribed the synthetic progestin, 17α-hydroxyprogesterone caproate (17-OHPC) during the middle trimester of pregnancy. However, little is known about the long-term behavioural effects of 17-OHPC. Work in rodents suggests that the developing brain is sensitive to progestins. Neonatal 17-OHPC impairs adult performance in set-shifting and delay discounting. The present study tested the effects of 17-OHPC (0.5 mg kg
Identifiants
pubmed: 32485009
doi: 10.1111/jne.12862
pmc: PMC8130846
mid: NIHMS1698522
doi:
Substances chimiques
17 alpha-Hydroxyprogesterone Caproate
276F2O42F5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12862Subventions
Organisme : NICHD NIH HHS
ID : R01 HD093907
Pays : United States
Organisme : NIH HHS
ID : R01-HD093907
Pays : United States
Informations de copyright
© 2020 British Society for Neuroendocrinology.
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