Effect of Proton Pump Inhibitors on Colorectal Cancer.
Animals
Apoptosis
Cell Line, Tumor
Cell Proliferation
Clostridium perfringens
/ metabolism
Colorectal Neoplasms
/ drug therapy
Cyclin D1
/ metabolism
Enterotoxins
/ chemistry
Extracellular Signal-Regulated MAP Kinases
/ metabolism
Feces
Gastrins
/ blood
Hydrogen-Ion Concentration
Liver Neoplasms
/ secondary
Male
Mice
Mice, Inbred BALB C
Mitochondria
/ metabolism
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasm Transplantation
Oxidative Stress
Proton Pump Inhibitors
/ pharmacology
Clostridium perfringens
YAP
gastrin
pH
proton pump inhibitor
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 May 2020
29 May 2020
Historique:
received:
13
04
2020
revised:
19
05
2020
accepted:
20
05
2020
entrez:
4
6
2020
pubmed:
4
6
2020
medline:
31
3
2021
Statut:
epublish
Résumé
Proton pump inhibitors (PPIs) are administered commonly to aged people; however, their effect on colorectal cancer (CRC) has still not been fully elucidated. Here, we examined the effect of PPIs and consequent alkalization on CRC cells. PPI administration alkalized the fecal pH and increased serum gastrin concentration. PPI and pH8 treatment (alkalization) of CMT93 mouse colon cancer cells inhibited cell growth and invasion, increased oxidative stress and apoptosis, and decreased mitochondrial volume and protein levels of cyclin D1 and phosphorylated extracellular signal-regulated kinase (pERK) 1/2. In contrast, gastrin treatment enhanced growth and invasion, decreased oxidative stress and apoptosis, and increased mitochondrial volume and cyclin D1 and pERK1/2 levels. Concurrent treatment with a PPI, pH8, and gastrin increased aldehyde dehydrogenase activity and also enhanced liver metastasis in the BALB/c strain of mice. PPI administration was associated with
Identifiants
pubmed: 32485921
pii: ijms21113877
doi: 10.3390/ijms21113877
pmc: PMC7312442
pii:
doi:
Substances chimiques
Ccnd1 protein, mouse
0
Enterotoxins
0
Gastrins
0
Proton Pump Inhibitors
0
enterotoxin, Clostridium
0
Cyclin D1
136601-57-5
Extracellular Signal-Regulated MAP Kinases
EC 2.7.11.24
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 16H05164
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 17K19923
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 18K17726
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 18K16671
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 19K19332
Organisme : Ministry of Education, Culture, Sports, Science and Technology
ID : 19K16564
Organisme : National Natural Science Foundation of China
ID : 81702723
Organisme : Natural Science Foundation of Jiangsu Education Department Project
ID : 17KJB320010
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