Post-Burn Pruritus.
Animals
Antipsychotic Agents
/ pharmacology
Burns
/ complications
Gabapentin
/ pharmacology
Histamine Antagonists
/ pharmacology
Humans
Inflammation
Keratinocytes
/ metabolism
Narcotic Antagonists
/ pharmacology
Neuropeptides
/ metabolism
Ondansetron
/ pharmacology
Pregabalin
/ pharmacology
Pruritus
/ drug therapy
Receptors, Opioid
/ agonists
Wound Healing
GABA
TRPV
antidepressant
burn
neuroleptic agent
neuropathy
opioid antagonist
pruritus
sensitization
substance P
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 May 2020
29 May 2020
Historique:
received:
08
04
2020
revised:
21
05
2020
accepted:
21
05
2020
entrez:
4
6
2020
pubmed:
4
6
2020
medline:
31
3
2021
Statut:
epublish
Résumé
Post-burn pruritus is the pruritus that occurs after burn during the rehabilitation and healing process of burn wounds. The post-burn pruritus is a common and serious complication of burn injury, which severely lowers the quality of life of the patient. Many potential treatments are available for pruritus but there is no consensus of the best single treatment yet. The precise mechanism of post-burn pruritus has not been elucidated, but it appears to have pruritogenic and neuropathic aspects. Clinically, post-burn pruritus tends to be intractable to conventional treatment but rather responds to neuroleptic agents, such as gabapentin and pregabalin. During wound healing, various neuropeptides secreted from the nerves of the skin control epidermal and vascular proliferation and connective tissue cells. When keratinocytes are activated by an itch-inducing substance, they secrete a variety of inflammatory substances that increase the susceptibility of the itch receptor. There are two mechanisms underlying post-burn neuropathic pruritus. The first one is peripheral sensitization. The second one is the intact nociceptor hypothesis. An effective treatment for post-burn pruritus will also be effective in other neuropathic and intractable itching. In this review, we summarized the interaction and mechanism of keratinocytes, immune cells, and nerve fibers related to post-burn pruritus.
Identifiants
pubmed: 32485929
pii: ijms21113880
doi: 10.3390/ijms21113880
pmc: PMC7313087
pii:
doi:
Substances chimiques
Antipsychotic Agents
0
Histamine Antagonists
0
Narcotic Antagonists
0
Neuropeptides
0
Receptors, Opioid
0
Ondansetron
4AF302ESOS
Pregabalin
55JG375S6M
Gabapentin
6CW7F3G59X
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Science and ICT, South Korea
ID : NRF- 2015M2A2A6A04044376
Organisme : Ministry of Health and Welfare
ID : HI17C0597
Organisme : Hallym University
ID : HURF-2017-83
Organisme : Hallym University
ID : HURF-2018-67
Organisme : Hallym University
ID : HURF-2019-72
Organisme : Ministry of Science and ICT, South Korea
ID : 2017R1A2B4006252
Organisme : Ministry of Science and ICT, South Korea
ID : 2018R1C1B6007998
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