Mitochondria: A Galaxy in the Hematopoietic and Leukemic Stem Cell Universe.
Animals
Apoptosis
Cell Differentiation
Cell Lineage
Cell Survival
Cell Transformation, Neoplastic
/ metabolism
Gene Expression Regulation, Leukemic
Hematologic Neoplasms
/ metabolism
Hematopoietic Stem Cells
/ metabolism
Humans
Leukemia
/ metabolism
Mice
Mitochondria
/ metabolism
Mitophagy
Neoplastic Stem Cells
/ metabolism
Oxidative Phosphorylation
Proto-Oncogene Proteins c-bcl-2
/ metabolism
Reactive Oxygen Species
/ metabolism
Signal Transduction
apoptosis
hematopoietic stem cell
leukemia
leukemic stem cell
mitochondria
mitochondrial dysfunction
mitochondrial targeted therapy
mitophagy
oxidative phosphorylation program
reactive oxygen species (ROS)
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
30 May 2020
30 May 2020
Historique:
received:
29
04
2020
revised:
24
05
2020
accepted:
28
05
2020
entrez:
4
6
2020
pubmed:
4
6
2020
medline:
1
4
2021
Statut:
epublish
Résumé
Mitochondria are the main fascinating energetic source into the cells. Their number, shape, and dynamism are controlled by the cell's type and current behavior. The perturbation of the mitochondrial inward system via stress response and/or oncogenic insults could activate several trafficking molecular mechanisms with the intention to solve the problem. In this review, we aimed to clarify the crucial pathways in the mitochondrial system, dissecting the different metabolic defects, with a special emphasis on hematological malignancies. We investigated the pivotal role of mitochondria in the maintenance of hematopoietic stem cells (HSCs) and their main alterations that could induce malignant transformation, culminating in the generation of leukemic stem cells (LSCs). In addition, we presented an overview of LSCs mitochondrial dysregulated mechanisms in terms of (1) increasing in oxidative phosphorylation program (OXPHOS), as a crucial process for survival and self-renewal of LSCs,(2) low levels of reactive oxygen species (ROS), and (3) aberrant expression of B-cell lymphoma 2 (Bcl-2) with sustained mitophagy. Furthermore, these peculiarities may represent attractive new "hot spots" for mitochondrial-targeted therapy. Finally, we remark the potential of the LCS metabolic effectors to be exploited as novel therapeutic targets.
Identifiants
pubmed: 32486249
pii: ijms21113928
doi: 10.3390/ijms21113928
pmc: PMC7312164
pii:
doi:
Substances chimiques
BCL2 protein, human
0
Proto-Oncogene Proteins c-bcl-2
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Cell Stem Cell. 2013 Mar 7;12(3):329-41
pubmed: 23333149
Clin Cancer Res. 2016 Sep 1;22(17):4440-51
pubmed: 27103402
Cancer Cell. 2011 Nov 15;20(5):674-88
pubmed: 22094260
Stem Cell Res. 2013 Sep;11(2):806-19
pubmed: 23792436
Nature. 2014 Oct 30;514(7524):628-32
pubmed: 25119024
Nat Rev Mol Cell Biol. 2010 Sep;11(9):655-67
pubmed: 20729931
Semin Hematol. 1997 Oct;34(4 Suppl 5):9-19
pubmed: 9408956
Nature. 2017 Mar 9;543(7644):205-210
pubmed: 28241143
Blood. 2020 Feb 13;135(7):463-471
pubmed: 31841594
Nat Cell Biol. 2000 Aug;2(8):553-5
pubmed: 10934477
Clin Cancer Res. 2019 Jul 1;25(13):4079-4090
pubmed: 30940653
Genomics Proteomics Bioinformatics. 2007 Dec;5(3-4):166-76
pubmed: 18267298
Cell Stem Cell. 2016 Mar 3;18(3):303-4
pubmed: 26942848
Clin Cancer Res. 2018 Oct 15;24(20):4931-4936
pubmed: 29769206
Free Radic Biol Med. 2007 Aug 15;43(4):477-503
pubmed: 17640558
Front Physiol. 2013 May 30;4:126
pubmed: 23755021
Mol Carcinog. 2014 Jun;53(6):498-504
pubmed: 23192887
Science. 1997 Feb 21;275(5303):1132-6
pubmed: 9027315
Eur J Haematol. 2013 Oct;91(4):295-303
pubmed: 23826975
N Engl J Med. 2016 Jan 28;374(4):311-22
pubmed: 26639348
Biochim Biophys Acta. 2013 Nov-Dec;1827(11-12):1278-94
pubmed: 23201476
Nature. 2005 Jun 2;435(7042):677-81
pubmed: 15902208
Cancer Res. 1979 Aug;39(8):3119-28
pubmed: 582296
Cell Commun Adhes. 2005 Jul-Dec;12(5-6):307-17
pubmed: 16531325
Front Oncol. 2019 Mar 27;9:192
pubmed: 30972300
Int J Hematol. 2017 Jul;106(1):18-26
pubmed: 28540498
Blood. 2005 Nov 1;106(9):3150-9
pubmed: 16014563
Cell. 2014 Sep 11;158(6):1309-1323
pubmed: 25215489
J Exp Clin Cancer Res. 2018 Jun 26;37(1):125
pubmed: 29940987
Neuropsychopharmacology. 2019 Apr;44(5):837-849
pubmed: 29855563
Physiol Rev. 2007 Jan;87(1):99-163
pubmed: 17237344
Cell. 2007 Jan 26;128(2):309-23
pubmed: 17254969
Ann Med. 2012 Feb;44(1):41-59
pubmed: 21806499
Science. 2001 Apr 27;292(5517):727-30
pubmed: 11326099
Cancer Cell. 2002 Sep;2(3):183-92
pubmed: 12242151
Cancers (Basel). 2018 May 06;10(5):
pubmed: 29734785
Leuk Lymphoma. 2017 Sep;58(9):1-17
pubmed: 28140720
Mov Disord. 2016 Mar;31(3):352-9
pubmed: 26853899
Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10190-5
pubmed: 21646527
EMBO J. 2008 Jan 23;27(2):433-46
pubmed: 18200046
J Biol Chem. 2002 Jun 7;277(23):20336-42
pubmed: 11916965
Toxicol Sci. 2010 Jul;116(1):140-50
pubmed: 20338993
Stem Cells Int. 2017;2017:2874283
pubmed: 28804500
EMBO Rep. 2018 May;19(5):
pubmed: 29661859
Pediatr Neurol. 2008 Oct;39(4):223-35
pubmed: 18805359
Cell Stem Cell. 2016 Jul 7;19(1):23-37
pubmed: 27374788
Nature. 2017 May 25;545(7655):500-504
pubmed: 28514443
Cell Mol Life Sci. 2014 Feb;71(4):575-97
pubmed: 23771628
Am J Hematol. 2002 Jun;70(2):115-25
pubmed: 12111784
Diseases. 2016 Dec 23;5(1):
pubmed: 28933354
Haematologica. 2020 Mar;105(3):697-707
pubmed: 31123034
Nature. 2017 Nov 16;551(7680):384-388
pubmed: 29144447
Nat Rev Cancer. 2004 Nov;4(11):891-9
pubmed: 15516961
J Huntingtons Dis. 2016;5(1):19-32
pubmed: 27031731
Cancer Discov. 2018 Dec;8(12):1566-1581
pubmed: 30185627
Blood. 2016 Jun 23;127(25):3215-24
pubmed: 27069256
Antioxidants (Basel). 2019 Oct 26;8(11):
pubmed: 31717825
J Cell Biol. 2019 Mar 4;218(3):909-928
pubmed: 30642892
Cancer Res. 2008 Jun 15;68(12):4875-81
pubmed: 18559535
Hematol Transfus Cell Ther. 2019 Apr - Jun;41(2):169-177
pubmed: 31084767
Cancer Lett. 2012 Dec 31;327(1-2):48-60
pubmed: 22182453
Front Pharmacol. 2019 Mar 22;10:203
pubmed: 30967773
Biol Blood Marrow Transplant. 2018 Oct;24(10):1997-2002
pubmed: 29933068
Cell Stem Cell. 2010 Aug 6;7(2):150-61
pubmed: 20682444
Blood. 2016 Sep 29;128(13):1671-8
pubmed: 27421961
Exp Hematol. 2018 Aug;64:1-11
pubmed: 29807063
IUBMB Life. 2001 Sep-Nov;52(3-5):159-64
pubmed: 11798028
Cell. 1999 Mar 19;96(6):857-68
pubmed: 10102273
Nat Cell Biol. 2011 May;13(5):589-98
pubmed: 21478857
Biochem Soc Trans. 2013 Oct;41(5):1312-6
pubmed: 24059525
Dev Cell. 2010 Apr 20;18(4):592-604
pubmed: 20412774
Nature. 1998 Nov 12;396(6707):133-40
pubmed: 9823893
Cell. 2007 Jan 26;128(2):325-39
pubmed: 17254970
Essays Biochem. 2018 Jul 20;62(3):255-270
pubmed: 30030361
Eur J Haematol. 2013 May;90(5):385-96
pubmed: 23444869
Science. 2012 Aug 31;337(6098):1062-5
pubmed: 22936770
Nature. 2017 Nov 23;551(7681):512-516
pubmed: 29132146
J Cell Physiol. 2011 Sep;226(9):2215-21
pubmed: 21660944
PLoS One. 2016 Nov 30;11(11):e0165582
pubmed: 27902785
J Biol Chem. 2005 Jul 15;280(28):26193-9
pubmed: 15905168
Curr Opin Hematol. 2015 Jul;22(4):324-9
pubmed: 26049753
Development. 2014 Nov;141(22):4206-18
pubmed: 25371358
Blood. 2015 Sep 10;126(11):1346-56
pubmed: 26186940
Annu Rev Genet. 2005;39:359-407
pubmed: 16285865
Nature. 2010 Oct 21;467(7318):929-34
pubmed: 20962839
Nat Med. 2018 Mar;24(3):360-367
pubmed: 29377004
Blood. 2012 Feb 9;119(6):1490-500
pubmed: 22144182
Biochim Biophys Acta Mol Cell Res. 2018 May;1865(5):721-733
pubmed: 29499228
Am J Cancer Res. 2017 Jul 01;7(7):1407-1422
pubmed: 28744393
Mol Cancer Res. 2003 Dec;1(14):1001-8
pubmed: 14707283
J Inherit Metab Dis. 2013 Sep;36(5):813-20
pubmed: 22991165
J Biol Chem. 2014 Apr 25;289(17):11873-96
pubmed: 24616095
J Exp Med. 2012 May 7;209(5):895-901
pubmed: 22508837
Best Pract Res Clin Endocrinol Metab. 2012 Dec;26(6):711-23
pubmed: 23168274
Blood Adv. 2019 Dec 23;3(24):4271-4279
pubmed: 31869414
Int J Hematol. 2013 Dec;98(6):648-57
pubmed: 23949914
Free Radic Biol Med. 2000 Aug;29(3-4):222-30
pubmed: 11035250
Sci Rep. 2018 Sep 5;8(1):13301
pubmed: 30185817
Biochem Biophys Res Commun. 2005 Jun 10;331(3):834-42
pubmed: 15865939
Cancer Cell. 2007 Aug;12(2):171-85
pubmed: 17692808
Lancet Oncol. 2009 Aug;10(8):764-71
pubmed: 19576851
J Biol Chem. 2007 Oct 12;282(41):30107-19
pubmed: 17711846
Cancer Cell. 2013 Aug 12;24(2):213-228
pubmed: 23911236
Biochem J. 2008 Jan 1;409(1):129-37
pubmed: 17894548
Cell Stem Cell. 2018 Jul 05;23(1):86-100.e6
pubmed: 29910151
Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1283-8
pubmed: 16432190
Ann Transl Med. 2020 Jan;8(1):17
pubmed: 32055608
Cell Calcium. 2016 Sep;60(3):199-206
pubmed: 26996063
Cancer Cell. 2010 Dec 14;18(6):553-67
pubmed: 21130701
Cancer Cell. 2018 Nov 12;34(5):724-740.e4
pubmed: 30423294
Cell Stem Cell. 2010 Sep 3;7(3):380-90
pubmed: 20804973
Nat Cell Biol. 2006 Dec;8(12):1348-58
pubmed: 17115033
Clin Cancer Res. 2017 Aug 15;23(16):4805-4816
pubmed: 28420723
Int J Mol Sci. 2018 Dec 05;19(12):
pubmed: 30563106
Leukemia. 2012 Feb;26(2):289-95
pubmed: 21826063
Nat Rev Mol Cell Biol. 2008 Jan;9(1):47-59
pubmed: 18097445
Cancer Cell. 2018 Aug 13;34(2):186-195
pubmed: 29805076
J Clin Oncol. 1988 May;6(5):919-25
pubmed: 3284977
Cell Death Differ. 2015 Sep;22(9):1399-401
pubmed: 26256515
Nature. 2002 Sep 19;419(6904):316-21
pubmed: 12239572
Nat Med. 2012 Sep;18(9):1350-8
pubmed: 22902876
Haematologica. 2018 Sep;103(9):e404-e407
pubmed: 29545346
Cancer Res. 2015 Jun 15;75(12):2478-88
pubmed: 26077472
PLoS One. 2016 Nov 28;11(11):e0166956
pubmed: 27893783
Biomed Res Int. 2013;2013:946206
pubmed: 24024216
Cell Stem Cell. 2020 Mar 5;26(3):420-430.e6
pubmed: 32059807
Nature. 1999 Feb 4;397(6718):441-6
pubmed: 9989411
Stem Cells Dev. 2014 Jan 15;23(2):83-94
pubmed: 24083546
Biochem J. 2009 Jan 1;417(1):1-13
pubmed: 19061483
Nat Med. 2006 Apr;12(4):446-51
pubmed: 16565722
Science. 2015 Apr 17;348(6232):340-3
pubmed: 25837514
J Biol Chem. 1996 Dec 20;271(51):32529-37
pubmed: 8955077
Ion Channels. 1996;4:169-202
pubmed: 8744209
Clin Cancer Res. 2009 Feb 15;15(4):1126-32
pubmed: 19228717
Curr Opin Cell Biol. 2008 Jun;20(3):303-9
pubmed: 18468877
Development. 2013 Jun;140(12):2535-47
pubmed: 23715547
Diagn Pathol. 2019 Jun 29;14(1):68
pubmed: 31253168
Acta Physiol (Oxf). 2009 May;196(1):65-80
pubmed: 19245654
Antioxid Redox Signal. 2011 May 15;14(10):1929-38
pubmed: 21194381
Cells. 2019 Jul 31;8(8):
pubmed: 31370337
Biochim Biophys Acta. 2006 Sep-Oct;1757(9-10):1406-20
pubmed: 16828051
Mol Cell. 2010 Nov 24;40(4):509-20
pubmed: 21095582
Blood. 2014 Sep 4;124(10):1645-54
pubmed: 25006128
Genes Dev. 2012 Sep 1;26(17):1926-44
pubmed: 22899010
J Clin Oncol. 2017 Dec 10;35(35):3964-3977
pubmed: 29068783
Cell Stem Cell. 2013 Jan 3;12(1):49-61
pubmed: 23290136
Biol Open. 2013 Jun 20;2(8):761-70
pubmed: 23951401
Adv Anat Pathol. 2012 Jul;19(4):193-203
pubmed: 22692282
Leukemia. 2017 Feb;31(2):272-281
pubmed: 27721426
Cell Cycle. 2015;14(1):56-63
pubmed: 25483068
Autophagy. 2017 Apr 3;13(4):761-762
pubmed: 28118076
Cell. 2012 Mar 16;148(6):1145-59
pubmed: 22424226
Int J Mol Sci. 2020 Jan 25;21(3):
pubmed: 31991829
Nat Med. 2018 Aug;24(8):1167-1177
pubmed: 30013198
Nat Rev Cancer. 2011 May;11(5):325-37
pubmed: 21508971
Science. 1984 Nov 30;226(4678):1097-9
pubmed: 6093263
Front Oncol. 2019 May 22;9:405
pubmed: 31192118
Trends Biochem Sci. 2016 Mar;41(3):261-273
pubmed: 26857402
Cell. 2000 Jan 7;100(1):57-70
pubmed: 10647931
Nature. 2010 Dec 2;468(7324):653-8
pubmed: 21124450
Redox Biol. 2013 Jan 18;1:45-9
pubmed: 24024136
J Clin Oncol. 2011 Feb 10;29(5):475-86
pubmed: 21220609
J Physiol. 2000 Nov 15;529 Pt 1:57-68
pubmed: 11080251
Cold Spring Harb Perspect Biol. 2013 Sep 01;5(9):
pubmed: 24003211
Mol Nutr Food Res. 2016 Aug;60(8):1804-18
pubmed: 27061349
Autophagy. 2013 Nov 1;9(11):1737-49
pubmed: 24135495
Aging (Albany NY). 2010 Sep;2(9):545-54
pubmed: 20876941
Mol Cell. 2008 Nov 21;32(4):529-39
pubmed: 19026783
Cell Stem Cell. 2013 Mar 7;12(3):269-70
pubmed: 23472867
Redox Biol. 2017 Aug;12:208-215
pubmed: 28259101
J Mol Biol. 2020 Jan 3;432(1):261-282
pubmed: 31260695
Blood. 2015 Oct 15;126(16):1925-9
pubmed: 26276667
Mol Cell. 2016 Mar 3;61(5):648-653
pubmed: 26942669
Cell Metab. 2006 Mar;3(3):177-85
pubmed: 16517405
Cell Death Differ. 2018 Jan;25(1):104-113
pubmed: 29149101
Dev Cell. 2002 Jan;2(1):55-67
pubmed: 11782314
Nature. 2016 Jan 28;529(7587):528-31
pubmed: 26789249
J Biol Chem. 2008 Oct 31;283(44):29730-9
pubmed: 18772130
Blood. 2019 Jul 25;134(4):389-394
pubmed: 31101624
Ann N Y Acad Sci. 2005 Jun;1044:1-5
pubmed: 15958691
Blood. 2012 Dec 13;120(25):4973-81
pubmed: 23091297
Front Oncol. 2020 Feb 18;10:155
pubmed: 32133293
Acta Oncol. 2017 Apr;56(4):503-515
pubmed: 28358664
Nat Med. 2018 Jul;24(7):1036-1046
pubmed: 29892070
Cell. 2016 Sep 8;166(6):1371-1385
pubmed: 27610564
Biochim Biophys Acta. 2014 Dec;1846(2):326-41
pubmed: 24880135
Cell Death Differ. 2016 Jan;23(1):182
pubmed: 26611459
Nat Cell Biol. 2017 Jul;19(7):856-863
pubmed: 28628083
Rev Environ Contam Toxicol. 2014;232:1-44
pubmed: 24984833
Front Genet. 2015 Apr 09;6:134
pubmed: 25914718
Annu Rev Biochem. 2007;76:723-49
pubmed: 17263664
Cancer. 2000 Nov 1;89(9):1976-82
pubmed: 11064355
Blood. 2017 Mar 9;129(10):1320-1332
pubmed: 28049638
Wiley Interdiscip Rev Syst Biol Med. 2010 Nov-Dec;2(6):640-53
pubmed: 20890962
Cell Stem Cell. 2011 Oct 4;9(4):298-310
pubmed: 21982230
J Biol Chem. 2001 Mar 23;276(12):9519-25
pubmed: 11120745
Antioxid Redox Signal. 2006 Mar-Apr;8(3-4):417-37
pubmed: 16677088
Cancer Cell. 2017 Oct 9;32(4):490-505.e10
pubmed: 29017059
Am J Cardiol. 2008 Jun 2;101(11A):22E-25E
pubmed: 18514622
Crit Rev Oncol Hematol. 2019 Dec;144:102814
pubmed: 31593878
EMBO J. 2016 Jan 18;35(2):208-36
pubmed: 26702098
Mol Cell. 2014 Sep 18;55(6):938-946
pubmed: 25175025
Biochim Biophys Acta. 2013 May;1827(5):552-64
pubmed: 23142170
Cell. 2013 Sep 26;155(1):160-71
pubmed: 24055366
Science. 1956 Feb 24;123(3191):309-14
pubmed: 13298683
Nature. 2019 Jan;565(7740):495-499
pubmed: 30626970