Role of serotonergic dorsal raphe neurons in hypercapnia-induced arousals.
Animals
Arousal
/ physiology
Brain Stem
/ metabolism
Calcitonin Gene-Related Peptide
/ metabolism
Carbon Dioxide
Disease Models, Animal
Dorsal Raphe Nucleus
/ metabolism
Hypercapnia
/ metabolism
Male
Mice
Mice, Transgenic
Optogenetics
Parabrachial Nucleus
Serotonergic Neurons
/ metabolism
Serotonin
/ genetics
Serotonin Plasma Membrane Transport Proteins
/ genetics
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
02 06 2020
02 06 2020
Historique:
received:
02
07
2019
accepted:
05
05
2020
entrez:
4
6
2020
pubmed:
4
6
2020
medline:
25
8
2020
Statut:
epublish
Résumé
During obstructive sleep apnea, elevation of CO
Identifiants
pubmed: 32488015
doi: 10.1038/s41467-020-16518-9
pii: 10.1038/s41467-020-16518-9
pmc: PMC7265411
doi:
Substances chimiques
Serotonin Plasma Membrane Transport Proteins
0
Slc6a4 protein, mouse
0
Carbon Dioxide
142M471B3J
Serotonin
333DO1RDJY
Calcitonin Gene-Related Peptide
JHB2QIZ69Z
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2769Subventions
Organisme : NINDS NIH HHS
ID : R01 NS073613
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS085477
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS112175
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL149630
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL095491
Pays : United States
Références
Bonsignore, M. R. et al. Metabolic syndrome, insulin resistance and sleepiness in real-life obstructive sleep apnoea. Eur. Respir. J. 39, 1136–1143 (2012).
pubmed: 22075482
doi: 10.1183/09031936.00151110
Mannarino, M. R., Di, F. F. & Pirro, M. Obstructive sleep apnea syndrome. Eur. J. Intern. Med. 23, 586–593 (2012).
pubmed: 22939801
doi: 10.1016/j.ejim.2012.05.013
Ayalon, L. & Peterson, S. Functional central nervous system imaging in the investigation of obstructive sleep apnea. Curr. Opin. Pulm. Med. 13, 479–483 (2007).
pubmed: 17901752
doi: 10.1097/MCP.0b013e3282f0e9fb
Benarroch, E. E. Brainstem respiratory control: substrates of respiratory failure of multiple system atrophy. Mov. Disord. 22, 155–161 (2007).
pubmed: 17133520
doi: 10.1002/mds.21236
Berry, R. B. & Gleeson, K. Respiratory arousal from sleep: mechanisms and significance. Sleep 20, 654–675 (1997).
pubmed: 9351134
doi: 10.1093/sleep/20.8.654
Gleeson, K., Zwillich, C. W. & White, D. P. The influence of increasing ventilatory effort on arousal from sleep. Am. Rev. Respir. Dis. 142, 295–300 (1990).
pubmed: 2382892
doi: 10.1164/ajrccm/142.2.295
Kaur, S. et al. A genetically defined circuit for arousal from sleep during hypercapnia. Neuron 96, 1153–1167 (2017).
pubmed: 29103805
pmcid: 5720904
doi: 10.1016/j.neuron.2017.10.009
Veasey, S. C., Fornal, C. A., Metzler, C. W. & Jacobs, B. L. Response of serotonergic caudal raphe neurons in relation to specific motor activities in freely moving cats. J. Neurosci. 15, 5346–5359 (1995).
pubmed: 7623157
pmcid: 6577863
doi: 10.1523/JNEUROSCI.15-07-05346.1995
Veasey, S. C., Fornal, C. A., Metzler, C. W. & Jacobs, B. L. Single-unit responses of serotonergic dorsal raphe neurons to specific motor challenges in freely moving cats. Neuroscience 79, 161–169 (1997).
pubmed: 9178872
doi: 10.1016/S0306-4522(96)00673-2
Buchanan, G. F. & Richerson, G. B. Central serotonin neurons are required for arousal to CO
pubmed: 20805497
doi: 10.1073/pnas.1004587107
Hodges, M. R., Wehner, M., Aungst, J., Smith, J. C. & Richerson, G. B. Transgenic mice lacking serotonin neurons have severe apnea and high mortality during development. J. Neurosci. 29, 10341–10349 (2009).
pubmed: 19692608
pmcid: 2755228
doi: 10.1523/JNEUROSCI.1963-09.2009
Hodges, M. R. & Richerson, G. B. The role of medullary serotonin (5-HT) neurons in respiratory control: contributions to eupneic ventilation, CO
pubmed: 20133432
pmcid: 2867541
doi: 10.1152/japplphysiol.01270.2009
Buchanan, G. F., Smith, H. R., MacAskill, A. & Richerson, G. B. 5-HT2A receptor activation is necessary for CO
pubmed: 25925320
pmcid: 4507958
doi: 10.1152/jn.00213.2015
Margatho, L. O., Godino, A., Oliveira, F. R., Vivas, L. & Antunes-Rodrigues, J. Lateral parabrachial afferent areas and serotonin mechanisms activated by volume expansion. J. Neurosci. Res. 86, 3613–3621 (2008).
pubmed: 18683241
doi: 10.1002/jnr.21806
Miller, R. L., Stein, M. K. & Loewy, A. D. Serotonergic inputs to FoxP2 neurons of the pre-locus coeruleus and parabrachial nuclei that project to the ventral tegmental area. Neuroscience 193, 229–240 (2011).
pubmed: 21784133
pmcid: 3185334
doi: 10.1016/j.neuroscience.2011.07.008
Petrov, T., Krukoff, T. L. & Jhamandas, J. H. The hypothalamic paraventricular and lateral parabrachial nuclei receive collaterals from raphe nucleus neurons: a combined double retrograde and immunocytochemical study. J. Comp. Neurol. 318, 18–26 (1992).
pubmed: 1583154
doi: 10.1002/cne.903180103
Smith, H. R. et al. Dorsal raphe serotonin neurons mediate CO
pubmed: 29378860
pmcid: 5824737
doi: 10.1523/JNEUROSCI.2182-17.2018
Kaur, S. et al. Glutamatergic signaling from the parabrachial nucleus plays a critical role in hypercapnic arousal. J. Neurosci. 33, 7627–7640 (2013).
pubmed: 23637157
pmcid: 3674488
doi: 10.1523/JNEUROSCI.0173-13.2013
Block, C. H. & Hoffman, G. E. Neuropeptide and monoamine components of the parabrachial pontine complex. Peptides 8, 267–283 (1987).
pubmed: 2884646
doi: 10.1016/0196-9781(87)90102-1
Brust, R. D., Corcoran, A. E., Richerson, G. B., Nattie, E. & Dymecki, S. M. Functional and developmental identification of a molecular subtype of brain serotonergic neuron specialized to regulate breathing dynamics. Cell Rep. 9, 2152–2165 (2014).
pubmed: 25497093
pmcid: 4351711
doi: 10.1016/j.celrep.2014.11.027
Portas, C. M. & McCarley, R. W. Behavioral state-related changes of extracellular serotonin concentration in the dorsal raphe nucleus: a microdialysis study in the freely moving cat. Brain Res. 648, 306–312 (1994).
pubmed: 7922546
doi: 10.1016/0006-8993(94)91132-0
Sakai, K. Sleep-waking discharge profiles of dorsal raphe nucleus neurons in mice. Neuroscience 197, 200–224 (2011).
pubmed: 21958868
doi: 10.1016/j.neuroscience.2011.09.024
Wu, M. F. et al. Activity of dorsal raphe cells across the sleep-waking cycle and during cataplexy in narcoleptic dogs. J. Physiol. 554, 202–215 (2004).
pubmed: 14678502
doi: 10.1113/jphysiol.2003.052134
Cho, J. R. et al. Dorsal raphe dopamine neurons modulate arousal and promote wakefulness by salient stimuli. Neuron 94, 1205–1219 (2017).
pubmed: 28602690
doi: 10.1016/j.neuron.2017.05.020
Monti, J. M. The role of dorsal raphe nucleus serotonergic and non-serotonergic neurons, and of their receptors, in regulating waking and rapid eye movement (REM) sleep. Sleep. Med. Rev. 14, 319–327 (2010).
pubmed: 20153670
doi: 10.1016/j.smrv.2009.10.003
Portas, C. M. et al. On-line detection of extracellular levels of serotonin in dorsal raphe nucleus and frontal cortex over the sleep/wake cycle in the freely moving rat. Neuroscience 83, 807–814 (1998).
pubmed: 9483564
doi: 10.1016/S0306-4522(97)00438-7
Sakai, K. & Crochet, S. Differentiation of presumed serotonergic dorsal raphe neurons in relation to behavior and wake-sleep states. Neuroscience 104, 1141–1155 (2001).
pubmed: 11457597
doi: 10.1016/S0306-4522(01)00103-8
Urbain, N., Creamer, K. & Debonnel, G. Electrophysiological diversity of the dorsal raphe cells across the sleep-wake cycle of the rat. J. Physiol. 573, 679–695 (2006).
pubmed: 16613874
pmcid: 1779756
doi: 10.1113/jphysiol.2006.108514
Lu, J., Jhou, T. C. & Saper, C. B. Identification of wake-active dopaminergic neurons in the ventral periaqueductal gray matter. J. Neurosci. 26, 193–202 (2006).
pubmed: 16399687
pmcid: 6674316
doi: 10.1523/JNEUROSCI.2244-05.2006
McGlashon, J. M. et al. Central serotonergic neurons activate and recruit thermogenic brown and beige fat and regulate glucose and lipid homeostasis. Cell Metab. 21, 692–705 (2015).
pubmed: 25955206
pmcid: 4565052
doi: 10.1016/j.cmet.2015.04.008
Murray, N. M., Buchanan, G. F. & Richerson, G. B. Insomnia caused by serotonin depletion is due to hypothermia. Sleep 38, 1985–1993 (2015).
pubmed: 26194567
pmcid: 4667392
doi: 10.5665/sleep.5256
Ray, R. S. et al. Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition. Science 333, 637–642 (2011).
pubmed: 21798952
pmcid: 3729433
doi: 10.1126/science.1205295
Ito, H. et al. Analysis of sleep disorders under pain using an optogenetic tool: possible involvement of the activation of dorsal raphe nucleus-serotonergic neurons. Mol. Brain 6, 59 (2013).
pubmed: 24370235
pmcid: 3879646
doi: 10.1186/1756-6606-6-59
Fornal, C. A., Metzler, C. W., Mirescu, C., Stein, S. K. & Jacobs, B. L. Effects of standardized extracts of St. John’s wort on the single-unit activity of serotonergic dorsal Raphe neurons in awake cats: comparisons with fluoxetine and sertraline. Neuropsychopharmacology 25, 858–870 (2001).
pubmed: 11750179
doi: 10.1016/S0893-133X(01)00297-4
Severson, C. A., Wang, W., Pieribone, V. A., Dohle, C. I. & Richerson, G. B. Midbrain serotonergic neurons are central pH chemoreceptors. Nat. Neurosci. 6, 1139–1140 (2003).
pubmed: 14517544
doi: 10.1038/nn1130
Niebert, M. et al. Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network. PLoS. ONE 6, e21395 (2011).
pubmed: 21789169
pmcid: 3138749
doi: 10.1371/journal.pone.0021395
Chamberlin, N. L. & Saper, C. B. Topographic organization of respiratory responses to glutamate microstimulation of the parabrachial nucleus in the rat. J. Neurosci. 14, 6500–6510 (1994).
pubmed: 7965054
pmcid: 6577246
doi: 10.1523/JNEUROSCI.14-11-06500.1994
McKenna, J. T. et al. Basal Forebrain Parvalbumin Neurons Mediate Arousals from Sleep Induced by Hypercarbia or Auditory Stimuli. Curr. Biol in press (2020).
Palmiter, R. D. The parabrachial nucleus: CGRP neurons function as a general alarm. Trends Neurosci. 41, 280–293 (2018).
pubmed: 29703377
pmcid: 5929477
doi: 10.1016/j.tins.2018.03.007
Saper, C. B. The house alarm. Cell Metab. 23, 754–755 (2016).
pubmed: 27166934
doi: 10.1016/j.cmet.2016.04.021
Gong, S. et al. Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs. J. Neurosci. 27, 9817–9823 (2007).
pubmed: 17855595
pmcid: 6672645
doi: 10.1523/JNEUROSCI.2707-07.2007
Krashes, M. J. et al. An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger. Nature 507, 238–242 (2014).
pubmed: 24487620
pmcid: 3955843
doi: 10.1038/nature12956
Anaclet, C. et al. Basal forebrain control of wakefulness and cortical rhythms. Nat. Commun. 6, 8744 (2015).
pubmed: 26524973
pmcid: 4659943
doi: 10.1038/ncomms9744
Pedersen, N. P. et al. Supramammillary glutamate neurons are a key node of the arousal system. Nat. Commun. 8, 1405 (2017).
pubmed: 29123082
pmcid: 5680228
doi: 10.1038/s41467-017-01004-6
Herrera, C. G. et al. Hypothalamic feedforward inhibition of thalamocortical network controls arousal and consciousness. Nat. Neurosci. 19, 290–298 (2016).
pubmed: 26691833
doi: 10.1038/nn.4209
Kim, T. et al. Cortically projecting basal forebrain parvalbumin neurons regulate cortical gamma band oscillations. Proc. Natl Acad. Sci. USA 112, 3535–3540 (2015).
pubmed: 25733878
doi: 10.1073/pnas.1413625112
Stefanik, M. T. & Kalivas, P. W. Optogenetic dissection of basolateral amygdala projections during cue-induced reinstatement of cocaine seeking. Front. Behav. Neurosci. 7, 213 (2013).
pubmed: 24399945
pmcid: 3871970
doi: 10.3389/fnbeh.2013.00213
Fox, M. A., French, H. T., LaPorte, J. L., Blackler, A. R. & Murphy, D. L. The serotonin 5-HT(2A) receptor agonist TCB-2: a behavioral and neurophysiological analysis. Psychopharmacology 212, 13–23 (2010).
pubmed: 19823806
doi: 10.1007/s00213-009-1694-1
Abercrombie, M. Estimation of nuclear population from microtome sections. Anat. Rec. 94, 239–247 (1946).
pubmed: 21015608
doi: 10.1002/ar.1090940210
Guillery, R. W. On counting and counting errors. J. Comp. Neurol. 447, 1–7 (2002).
pubmed: 11967890
doi: 10.1002/cne.10221
Kim, J., Zhang, X., Muralidhar, S., LeBlanc, S. A. & Tonegawa, S. Basolateral to central amygdala neural circuits for appetitive behaviors. Neuron 93, 1464–1479 (2017).
pubmed: 5480398
pmcid: 5480398
doi: 10.1016/j.neuron.2017.02.034
Ferrari, L. L. et al. Regulation of lateral hypothalamic orexin activity by local GABAergic neurons. J. Neurosci. 38, 1588–1599 (2018).
pubmed: 29311142
pmcid: 5815356
doi: 10.1523/JNEUROSCI.1925-17.2017
Paxinos, G. & Franklin, K. B. J. The mouse brain in stereotaxic coordinates. 2nd Edition. Elsevier Academic Press, (2001).