Selegiline (L-Deprenyl) Mitigated Oxidative Stress, Cognitive Abnormalities, and Histopathological Change in Rats: Alternative Therapy in Transient Global Ischemia.
Behavioral abnormality
Oxidative stress
Selegiline
Transient global ischemia
Journal
Journal of molecular neuroscience : MN
ISSN: 1559-1166
Titre abrégé: J Mol Neurosci
Pays: United States
ID NLM: 9002991
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
25
01
2020
accepted:
13
04
2020
pubmed:
4
6
2020
medline:
30
6
2021
entrez:
4
6
2020
Statut:
ppublish
Résumé
Selegiline (L-deprenyl) is the major drug which is used in the treatment of Parkinson's disease because of its neurotrophic and antiapoptotic properties. Previous studies suggested that low dose of L-methamphetamine (L-METH) caused lower mortality rate in patients with severe traumatic brain injury. As L-methamphetamine is one of the metabolites of selegiline, the present study aims to examine whether L-deprenyl can improve cognitive, biochemical, and histopathological injury in animal model of transient global ischemia. The animals were randomized in ten groups orally gavaged three times a week for 28 days. Then, novel object recognition (NOR) was conducted to assess their behavioral abnormality. After scarification of the rats, their brains were divided into two sections to measure oxidative stress parameters and perform pathological evaluations in rats. Our data revealed the involvement of oxidative stress, behavioral despair, and pathological data in transient global ischemia rats. Significant recovery in cognitive behavior, oxidative stress biomarker, and number of dead cell in histopathological assay was observed in rats treated with 1,2 and 4 mg/kg of selegiline. So, selegiline appears to be useful in alternative therapy of transient global ischemia.
Identifiants
pubmed: 32488846
doi: 10.1007/s12031-020-01544-5
pii: 10.1007/s12031-020-01544-5
doi:
Substances chimiques
Antioxidants
0
Neuroprotective Agents
0
Selegiline
2K1V7GP655
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1639-1648Subventions
Organisme : Zanjan University of Medical Sciences
ID : A-12-769-24
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