New Role for Growth/Differentiation Factor 15 in the Survival of Transplanted Brown Adipose Tissues in Cooperation with Interleukin-6.
Adipocytes, Brown
/ metabolism
Adipose Tissue, Brown
/ transplantation
Animals
Cell Differentiation
/ genetics
Cell Line
Gene Expression Regulation
Growth Differentiation Factor 15
/ deficiency
Human Embryonic Stem Cells
/ cytology
Humans
Interleukin-6
/ metabolism
Mice, Knockout
Models, Biological
Tissue Survival
/ physiology
GDF15
IL6
brown adipocyte
human pluripotent stem cells
intraperitoneal transplantation
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
01 06 2020
01 06 2020
Historique:
received:
31
03
2020
revised:
18
05
2020
accepted:
27
05
2020
entrez:
5
6
2020
pubmed:
5
6
2020
medline:
6
3
2021
Statut:
epublish
Résumé
To identify factors involved in the earliest phase of the differentiation of human embryonic stem cells (hESCs) into brown adipocytes (BAs), we performed multi-time point microarray analyses. We found that growth/differentiation factor 15 (GDF15) expressions were specifically upregulated within three days of differentiation, when expressions of immature hESC markers were sustained. Although GDF15 expressions continued to increase in the subsequent differentiation phases,
Identifiants
pubmed: 32492819
pii: cells9061365
doi: 10.3390/cells9061365
pmc: PMC7349565
pii:
doi:
Substances chimiques
Growth Differentiation Factor 15
0
Interleukin-6
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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