Endothelial Damage, Inflammation and Immunity in Chronic Kidney Disease.
chronic kidney disease (CKD), uremia
endothelial cells
endothelial damage
inflammation
innate immunity
oxidative stress
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
01 06 2020
01 06 2020
Historique:
received:
28
04
2020
revised:
22
05
2020
accepted:
29
05
2020
entrez:
5
6
2020
pubmed:
5
6
2020
medline:
4
3
2021
Statut:
epublish
Résumé
Chronic kidney disease (CKD) patients have an accelerated atherosclerosis, increased risk of thrombotic-ischemic complications, and excessive mortality rates when compared with the general population. There is also evidence of an endothelial damage in which the proinflammatory state, the enhanced oxidative stress, or the accumulation of toxins due to their reduced renal clearance in uremia play a role. Further, there is evidence that uremic endothelial cells are both involved in and victims of the activation of the innate immunity. Uremic endothelial cells produce danger associated molecular patterns (DAMPS), which by binding to specific pattern recognition receptors expressed in multiple cells, including endothelial cells, induce the expression of adhesion molecules, the production of proinflammatory cytokines and an enhanced production of reactive oxygen species in endothelial cells, which constitute a link between immunity and inflammation. The connection between endothelial damage, inflammation and defective immunity in uremia will be reviewed here.
Identifiants
pubmed: 32492843
pii: toxins12060361
doi: 10.3390/toxins12060361
pmc: PMC7354562
pii:
doi:
Substances chimiques
Alarmins
0
Inflammation Mediators
0
Receptors, Pattern Recognition
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Instituto de Salud Carlos III
ID : PIE15/00027
Pays : International
Organisme : Instituto de Salud Carlos III
ID : FIS PI19/00888
Pays : International
Organisme : Generalitat de Catalunya
ID : 2017-SGR675
Pays : International
Organisme : Jazz Pharmaceuticals
ID : IST-16-10355
Pays : International
Organisme : Generalitat de Catalunya
ID : CERCA
Pays : International
Déclaration de conflit d'intérêts
There is no conflict of interest of the authors related to the contents of this review.
Références
PLoS One. 2015 Nov 16;10(11):e0142835
pubmed: 26580207
J Cachexia Sarcopenia Muscle. 2017 Feb;8(1):131-144
pubmed: 27897392
J Clin Invest. 1988 Feb;81(2):487-98
pubmed: 3276731
Atherosclerosis. 2011 Jun;216(2):446-51
pubmed: 21414625
BMC Nephrol. 2020 Apr 21;21(1):141
pubmed: 32316931
Am J Physiol Renal Physiol. 2018 Nov 1;315(5):F1430-F1443
pubmed: 30110570
Clin J Am Soc Nephrol. 2011 Jan;6(1):133-41
pubmed: 20876680
J Am Coll Cardiol. 2007 Jul 17;50(3):217-24
pubmed: 17631213
Gut. 1991 Jul;32(7):754-9
pubmed: 1855681
Nature. 2018 Aug;560(7717):198-203
pubmed: 30046112
Inflammation. 2019 Dec;42(6):2003-2010
pubmed: 31312972
Urol Res. 2004 Aug;32(4):266-70
pubmed: 15497213
J Immunol. 2013 Feb 1;190(3):1217-26
pubmed: 23267025
Acta Physiol (Oxf). 2017 Feb;219(2):382-408
pubmed: 27246807
Nephrol Dial Transplant. 2006 Jun;21(6):1603-10
pubmed: 16476720
Kidney Int. 2000 May;57(5):1905-14
pubmed: 10792609
Cytokine. 2013 Apr;62(1):22-33
pubmed: 23481102
Acta Physiol (Oxf). 2015 May;214(1):33-50
pubmed: 25677529
Int J Mol Sci. 2019 Jul 22;20(14):
pubmed: 31336567
Eur Heart J. 2014 Jul 14;35(27):1782-91
pubmed: 24864079
PLoS One. 2016 Nov 15;11(11):e0166050
pubmed: 27846250
Blood. 2017 May 11;129(19):2667-2679
pubmed: 28264799
Nature. 2012 Jan 18;481(7381):278-86
pubmed: 22258606
Toxins (Basel). 2020 Jan 21;12(2):
pubmed: 31973024
Eur J Immunol. 2014 Oct;44(10):3081-92
pubmed: 25042478
J Ren Nutr. 2012 Jan;22(1):149-56
pubmed: 22200433
Lancet. 2010 Jun 12;375(9731):2073-81
pubmed: 20483451
Adv Exp Med Biol. 2019;1165:407-421
pubmed: 31399976
Arterioscler Thromb Vasc Biol. 2003 Apr 1;23(4):656-60
pubmed: 12615675
Int Immunopharmacol. 2017 Feb;43:203-209
pubmed: 28038382
Semin Dial. 2011 May-Jun;24(3):327-37
pubmed: 21682773
J Am Soc Nephrol. 2019 Jun;30(6):918-928
pubmed: 31040188
Thromb Res. 2010 Mar;125(3):205-9
pubmed: 19945154
Cardiovasc Res. 2008 Mar 1;77(4):809-18
pubmed: 18065768
Nephrol Dial Transplant. 2011 Nov;26(11):3537-43
pubmed: 21378154
Am J Pathol. 1993 Sep;143(3):823-31
pubmed: 8362980
Exp Cell Res. 2018 Apr 15;365(2):157-162
pubmed: 29481790
Nat Rev Nephrol. 2019 Sep;15(9):531-545
pubmed: 31243394
Am J Nephrol. 2013;37(1):1-6
pubmed: 23258127
Toxins (Basel). 2018 Oct 12;10(10):
pubmed: 30322010
Nephrol Dial Transplant. 2012 Apr;27(4):1446-53
pubmed: 21873622
Kidney Int. 2013 Jun;83(6):1010-6
pubmed: 23325079
Front Immunol. 2014 Sep 25;5:461
pubmed: 25309543
J Leukoc Biol. 1994 May;55(5):662-75
pubmed: 8182345
Crit Care Clin. 2020 Apr;36(2):233-253
pubmed: 32172811
PLoS One. 2013 Aug 02;8(8):e72663
pubmed: 23936542
Immunity. 2013 Apr 18;38(4):754-68
pubmed: 23477738
Clin J Am Soc Nephrol. 2012 Dec;7(12):1938-46
pubmed: 23024164
Nephrol Dial Transplant. 2016 May;31(5):737-46
pubmed: 25883197
Antioxid Redox Signal. 2015 May 1;22(13):1111-29
pubmed: 25330206
Nephron. 2015;130(3):151-8
pubmed: 26089157
Eur J Heart Fail. 2016 Jun;18(6):588-98
pubmed: 26861140
Nat Immunol. 2015 Apr;16(4):343-53
pubmed: 25789684
Antonie Van Leeuwenhoek. 2016 Oct;109(10):1389-96
pubmed: 27431681
J Ren Nutr. 2018 Jul;28(4):259-264
pubmed: 29429793
Int J Cardiol. 2013 Oct 3;168(3):2242-7
pubmed: 23453445
Heart. 2000 Feb;83(2):205-9
pubmed: 10648498
Nephrol Dial Transplant. 2010 Aug;25(8):2571-6
pubmed: 20179005
Nephron Clin Pract. 2009;111(2):c117-26
pubmed: 19147993
J Am Soc Nephrol. 2009 Oct;20(10):2235-45
pubmed: 19608702
Kidney Int. 2006 Jul;70(2):358-62
pubmed: 16738534
Thromb Haemost. 2017 Jun 28;117(7):1296-1316
pubmed: 28569921
Kidney Int. 1995 Feb;47(2):510-7
pubmed: 7723236
Front Pharmacol. 2019 Nov 19;10:1360
pubmed: 31803054
Immunity. 2013 Jun 27;38(6):1142-53
pubmed: 23809161
Oncotarget. 2016 Apr 5;7(14):17479-91
pubmed: 27014913
Immunol Lett. 2004 May 15;93(2-3):109-13
pubmed: 15158605
J Clin Invest. 1985 Nov;76(5):2003-11
pubmed: 3877078
Blood. 1998 Jul 15;92(2):507-15
pubmed: 9657750
PLoS One. 2015 Jul 01;10(7):e0132047
pubmed: 26132137
J Thromb Haemost. 2007 Jun;5(6):1302-8
pubmed: 17403109
PLoS One. 2012;7(8):e43374
pubmed: 22937042
Kidney Int. 2015 Jan;87(1):74-84
pubmed: 25075770
Oncotarget. 2017 Apr 21;8(38):64520-64533
pubmed: 28969091
PLoS One. 2015 Mar 23;10(3):e0122272
pubmed: 25798846
Nephrol Dial Transplant. 2003 Jun;18(6):1079-85
pubmed: 12748338
Am J Kidney Dis. 2004 Feb;43(2):244-53
pubmed: 14750089
J Am Soc Nephrol. 2011 Jun;22(6):1007-18
pubmed: 21566058
Infect Immun. 1992 Apr;60(4):1536-43
pubmed: 1548077
Kidney Int. 2001 Apr;59(4):1382-9
pubmed: 11260399
Kidney Int. 2007 Nov;72(9):1081-7
pubmed: 17687255
Sci Rep. 2017 Jun 8;7(1):3057
pubmed: 28596556
Arch Toxicol. 2019 Jan;93(1):121-136
pubmed: 30324315
Kidney Int. 2004 Feb;65(2):700-4
pubmed: 14717944
Nat Immunol. 2010 Feb;11(2):136-40
pubmed: 20023662
Kidney Int. 2013 Feb;83(2):308-15
pubmed: 22992469
Atherosclerosis. 2020 Feb;294:17-24
pubmed: 31945614
Nefrologia. 2017 Jan - Feb;37(1):9-19
pubmed: 27553986
J Immunol. 2000 Dec 15;165(12):6682-6
pubmed: 11120784
Nat Med. 2010 Mar;16(3):279-85
pubmed: 20190767
J Gerontol A Biol Sci Med Sci. 2015 Oct;70(10):1198-209
pubmed: 25246106
Kidney Int. 2005 Mar;67(3):1078-83
pubmed: 15698448
Am J Nephrol. 2014;39(3):230-237
pubmed: 24643131
Am J Physiol Renal Physiol. 2014 Dec 1;307(11):F1302-11
pubmed: 25339701
BMC Nephrol. 2014 Jan 23;15:21
pubmed: 24450291
J Am Soc Nephrol. 2006 Feb;17(2):537-45
pubmed: 16382015
Kidney Res Clin Pract. 2015 Jun;34(2):76-82
pubmed: 26484026
Vascul Pharmacol. 2018 Apr 22;:
pubmed: 29684642
J Am Heart Assoc. 2018 Jan 4;7(1):
pubmed: 29301761
J Inflamm (Lond). 2016 Aug 02;13:25
pubmed: 27486384
Hemodial Int. 2019 Jan;23(1):58-68
pubmed: 30724445
Am J Kidney Dis. 2003 Oct;42(4):704-12
pubmed: 14520620
Nephrol Dial Transplant. 2019 Apr 08;:
pubmed: 31071222
Diabetes. 2015 Mar;64(3):947-59
pubmed: 25352635
Thromb Haemost. 2001 Oct;86(4):1099-105
pubmed: 11686330
Kidney Int. 2018 Aug;94(2):346-362
pubmed: 29861057
PLoS One. 2014 Jan 27;9(1):e87552
pubmed: 24475307
Toxins (Basel). 2018 Oct 07;10(10):
pubmed: 30301260
J Cell Commun Signal. 2017 Sep;11(3):275-279
pubmed: 28547650
Arterioscler Thromb Vasc Biol. 2004 Jul;24(7):1246-52
pubmed: 15155385
Nephrol Dial Transplant. 2012 May;27(5):1873-80
pubmed: 22036944
Am J Physiol Heart Circ Physiol. 2019 Oct 1;317(4):H695-H704
pubmed: 31398059
Lancet. 2020 Feb 29;395(10225):709-733
pubmed: 32061315
Pediatr Nephrol. 2010 Nov;25(11):2231-40
pubmed: 20424866
Am J Kidney Dis. 2008 Apr;51(4):603-12
pubmed: 18371536
Nephrol Dial Transplant. 2019 Feb 1;34(2):252-264
pubmed: 29718431
Int J Med Sci. 2016 Feb 20;13(3):240-7
pubmed: 26941585
J Surg Res. 2011 Aug;169(2):328-36
pubmed: 20371087
Am J Nephrol. 2010;31(5):435-41
pubmed: 20389059
Thromb Res. 2020 May;189:77-87
pubmed: 32192995
Am J Hypertens. 2020 Mar 30;:
pubmed: 32300778
Nephrology (Carlton). 2012 Nov;17(8):733-8
pubmed: 22817644
Lancet. 2012 Jan 14;379(9811):165-80
pubmed: 21840587
Dig Dis Sci. 2014 Sep;59(9):2109-17
pubmed: 24828917
Science. 2010 Jan 15;327(5963):296-300
pubmed: 20075245
PLoS One. 2015 Sep 23;10(9):e0138461
pubmed: 26398099
J Am Soc Nephrol. 2017 Nov;28(11):3251-3261
pubmed: 28696247
Clin J Am Soc Nephrol. 2009 Oct;4(10):1551-8
pubmed: 19696217
Clin J Am Soc Nephrol. 2008 Sep;3(5):1526-33
pubmed: 18701615
J Am Coll Cardiol. 2017 Oct 31;70(18):2278-2289
pubmed: 29073957
Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1622-30
pubmed: 19696406
Cell Physiol Biochem. 2018;51(3):1287-1300
pubmed: 30481789
PLoS One. 2010 Jul 08;5(7):e11477
pubmed: 20628606
Int J Mol Med. 2007 May;19(5):783-90
pubmed: 17390084
Toxins (Basel). 2020 Apr 05;12(4):
pubmed: 32260489
Clin Kidney J. 2019 Jun 17;13(1):72-74
pubmed: 32082555
Trends Immunol. 2004 Sep;25(9):489-95
pubmed: 15324742
Clin J Am Soc Nephrol. 2008 Mar;3(2):505-21
pubmed: 18184879
Nephrol Dial Transplant. 2007 Feb;22(2):409-16
pubmed: 17082211
Front Immunol. 2019 Jun 28;10:1478
pubmed: 31316518
J Am Soc Nephrol. 2015 Apr;26(4):876-87
pubmed: 25145928
Exp Gerontol. 1999 Jul;34(4):513-25
pubmed: 10817807
Nephrol Dial Transplant. 2012 May;27(5):1867-72
pubmed: 21976741
Nature. 2011 Apr 7;472(7341):57-63
pubmed: 21475195
Atherosclerosis. 2015 Apr;239(2):393-400
pubmed: 25682038
J Am Soc Nephrol. 2010 Oct;21(10):1732-44
pubmed: 20688930
Clin J Am Soc Nephrol. 2020 Mar 6;15(3):359-366
pubmed: 32075807
Heart Lung Circ. 2013 Sep;22(9):746-50
pubmed: 23462287
J Thromb Haemost. 2006 Mar;4(3):566-73
pubmed: 16405517
Lancet. 2013 Jul 20;382(9888):260-72
pubmed: 23727169
Int J Mol Sci. 2020 Mar 31;21(7):
pubmed: 32244284
Curr Hematol Rep. 2005 Sep;4(5):359-67
pubmed: 16131436
Nat Rev Immunol. 2013 Oct;13(10):738-53
pubmed: 24037418
Eur Heart J Cardiovasc Imaging. 2014 Jan;15(1):56-61
pubmed: 23811493
Lancet. 1992 Mar 7;339(8793):572-5
pubmed: 1347093
Lancet. 2001 Dec 22-29;358(9299):2113-7
pubmed: 11784625
Am J Nephrol. 1996;16(4):293-9
pubmed: 8739281
Trends Immunol. 2018 May;39(5):393-406
pubmed: 29452983
Nat Rev Nephrol. 2019 Aug;15(8):501-520
pubmed: 31164720
Adv Med Sci. 2010;55(2):196-203
pubmed: 20439183
J Immunol. 2007 May 15;178(10):6017-22
pubmed: 17475823
Blood. 1998 May 15;91(10):3527-61
pubmed: 9572988
Cell Death Differ. 2007 Sep;14(9):1583-9
pubmed: 17599094
Am J Kidney Dis. 2009 Nov;54(5):891-901
pubmed: 19615803
J Clin Invest. 1990 Mar;85(3):731-8
pubmed: 2312724
Nature. 2011 Jan 13;469(7329):221-5
pubmed: 21124315
Eur J Clin Invest. 2015 Feb;45(2):160-9
pubmed: 25496217
Kidney Int. 2013 Oct;84(4):733-44
pubmed: 23636172
Am J Physiol Renal Physiol. 2009 Jun;296(6):F1314-22
pubmed: 19339628
J Pharmacol Toxicol Methods. 2018 Jan - Feb;89:39-46
pubmed: 29056520
Cardiovasc Res. 2005 Dec 1;68(3):353-4
pubmed: 16253212
Nephrology (Carlton). 2016 Sep;21(9):736-44
pubmed: 27011059
Kidney Int. 1990 Jan;37(1):116-25
pubmed: 2299797
Haematologica. 2002 Oct;87(10):1053-61
pubmed: 12368160
Kidney Int. 2013 Feb;83(2):213-22
pubmed: 22913982
N Engl J Med. 2016 Dec 15;375(24):2369-2379
pubmed: 27974040
J Cell Mol Med. 2015 Dec;19(12):2715-27
pubmed: 26293846