Frontoparietal structural properties mediate adult life span differences in executive function.
Adult
Aged
Aged, 80 and over
Anisotropy
Brain Mapping
/ methods
Cognition
/ physiology
Executive Function
/ physiology
Female
Frontal Lobe
/ physiology
Gray Matter
/ physiology
Humans
Longevity
/ physiology
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Nerve Net
/ physiology
Neuropsychological Tests
White Matter
/ physiology
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
03 06 2020
03 06 2020
Historique:
received:
30
08
2019
accepted:
15
05
2020
entrez:
5
6
2020
pubmed:
5
6
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Executive function (EF) refers to a set of cognitive functions that support goal-directed behaviors. Recent findings have suggested that the frontoparietal network (FPN) subserves neural processes that are related to EF. However, the FPN structural and functional network properties that mediate age-related differences in EF components remain unclear. To this end, we used three experimental tasks to test the component processes of EF based on Miyake and Friedman's model: one common EF component process (incorporating inhibition, shifting, and updating) and two specific EF component processes (shifting and updating). We recruited 126 healthy participants (65 females; 20 to 78 years old) who underwent both structural and functional MRI scanning. We tested a mediation path model of three structural and functional properties of the FPN (i.e., gray matter volume, white matter fractional anisotropy, and intra/internetwork functional connectivity) as mediators of age-related differences in the three EF components. The results indicated that age-related common EF component differences are mediated by regional gray matter volume changes in both hemispheres of the frontal lobe, which suggests that structural changes in the frontal lobe may have an indirect influence on age-related general elements of EF. These findings suggest that the FPN mediates age-related differences in specific components of EF.
Identifiants
pubmed: 32494018
doi: 10.1038/s41598-020-66083-w
pii: 10.1038/s41598-020-66083-w
pmc: PMC7271169
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9066Références
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