Role of the pyruvate metabolic network on carbohydrate metabolism and virulence in Streptococcus pneumoniae.
Animals
Bacterial Proteins
/ metabolism
Carbohydrate Metabolism
/ physiology
Carbohydrates
/ physiology
Female
Galactose
/ metabolism
Glycolysis
Hydrogen Peroxide
/ metabolism
Metabolic Networks and Pathways
Mice
Mice, Inbred BALB C
Pyruvic Acid
/ metabolism
Streptococcus pneumoniae
/ enzymology
Virulence
/ physiology
Streptococcus pneumoniae
capsule production
carbohydrate metabolism
pyruvate
virulence
Journal
Molecular microbiology
ISSN: 1365-2958
Titre abrégé: Mol Microbiol
Pays: England
ID NLM: 8712028
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
06
02
2020
revised:
27
04
2020
accepted:
22
05
2020
pubmed:
5
6
2020
medline:
14
7
2021
entrez:
5
6
2020
Statut:
ppublish
Résumé
Streptococcus pneumoniae is a major human pathogen that must adapt to unique nutritional environments in several host niches. The pneumococcus can metabolize a range of carbohydrates that feed into glycolysis ending in pyruvate, which is catabolized by several enzymes. We investigated how the pneumococcus utilizes these enzymes to metabolize different carbohydrates and how this impacts survival in the host. Loss of ldh decreased bacterial burden in the nasopharynx and enhanced bacteremia in mice. Loss of spxB, pdhC or pfl2 decreased bacteremia and increased host survival. In glucose or galactose, loss of ldh increased capsule production, whereas loss of spxB and pdhC reduced capsule production. The pfl2 mutant exhibited reduced capsule production only in galactose. In glucose, pyruvate was metabolized primarily by LDH to generate lactate and NAD
Identifiants
pubmed: 32495474
doi: 10.1111/mmi.14557
pmc: PMC8538403
mid: NIHMS1741751
doi:
Substances chimiques
Bacterial Proteins
0
Carbohydrates
0
Pyruvic Acid
8558G7RUTR
Hydrogen Peroxide
BBX060AN9V
Galactose
X2RN3Q8DNE
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
536-552Subventions
Organisme : NIAID NIH HHS
ID : R01 AI110618
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM034496
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI124302
Pays : United States
Informations de copyright
© 2020 John Wiley & Sons Ltd.
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