Drug metabolising enzyme polymorphisms and chemotherapy-related ovarian failure in young breast cancer survivors.
Adult
Alleles
Antineoplastic Agents, Alkylating
/ adverse effects
Breast Neoplasms
/ drug therapy
Cancer Survivors
Cyclophosphamide
/ adverse effects
Cytochrome P-450 CYP2C19
/ genetics
Cytochrome P-450 CYP3A
/ genetics
Female
Genotype
Glutathione S-Transferase pi
/ genetics
Glutathione Transferase
/ genetics
Humans
Longitudinal Studies
Pharmacogenomic Variants
/ drug effects
Polymorphism, Single Nucleotide
Primary Ovarian Insufficiency
/ chemically induced
Proportional Hazards Models
Prospective Studies
Young Adult
Breast cancer
CYP2C19
CYP3A4; GSTP1
GSTA1
ovarian failure
Journal
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
ISSN: 1364-6893
Titre abrégé: J Obstet Gynaecol
Pays: England
ID NLM: 8309140
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
pubmed:
5
6
2020
medline:
15
11
2022
entrez:
5
6
2020
Statut:
ppublish
Résumé
Cyclophosphamide is associated with chemotherapy-related ovarian failure (CROF) in breast cancer survivors, however little is known about predicting individual risks. We sought to identify genetic alleles as biomarkers for risk of CROF after cyclophosphamide treatment. One hundred fifteen premenopausal women with newly diagnosed breast cancer were genotyped for single nucleotide polymorphisms (SNPs) in genes involved in cyclophosphamide activation (
Identifiants
pubmed: 32496149
doi: 10.1080/01443615.2020.1754369
pmc: PMC9647890
mid: NIHMS1831230
doi:
Substances chimiques
Antineoplastic Agents, Alkylating
0
Cyclophosphamide
8N3DW7272P
CYP2C19 protein, human
EC 1.14.14.1
Cytochrome P-450 CYP2C19
EC 1.14.14.1
Cytochrome P-450 CYP3A
EC 1.14.14.1
CYP3A4 protein, human
EC 1.14.14.55
GSTA1 protein, human
EC 2.5.1.18
GSTP1 protein, human
EC 2.5.1.18
Glutathione S-Transferase pi
EC 2.5.1.18
Glutathione Transferase
EC 2.5.1.18
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
447-452Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD080952
Pays : United States
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