Minimal clinically important difference for asthma endpoints: an expert consensus report.

Anti-Asthmatic Agents / therapeutic use Asthma / diagnosis Biomarkers / metabolism Bronchoconstriction / drug effects Consensus Delphi Technique Endpoint Determination Humans Inflammation Mediators / metabolism Lung / drug effects Minimal Clinically Important Difference Predictive Value of Tests Symptom Assessment Treatment Outcome

Journal

European respiratory review : an official journal of the European Respiratory Society
ISSN: 1600-0617
Titre abrégé: Eur Respir Rev
Pays: England
ID NLM: 9111391

Informations de publication

Date de publication:
30 Jun 2020
Historique:
received: 25 10 2019
accepted: 09 03 2020
entrez: 6 6 2020
pubmed: 6 6 2020
medline: 7 4 2021
Statut: epublish

Résumé

Minimal clinically important difference (MCID) can be defined as the smallest change or difference in an outcome measure that is perceived as beneficial and would lead to a change in the patient's medical management.The aim of the current expert consensus report is to provide a "state-of-the-art" review of the currently available literature evidence about MCID for end-points to monitor asthma control, in order to facilitate optimal disease management and identify unmet needs in the field to guide future research.A series of MCID cut-offs are currently available in literature and validated among populations of asthmatic patients, with most of the evidence focusing on outcomes as patient reported outcomes, lung function and exercise tolerance. On the contrary, only scant and partial data are available for inflammatory biomarkers. These clearly represent the most interesting target for future development in diagnosis and clinical management of asthma, particularly in view of the several biologic drugs in the pipeline, for which regulatory agencies will soon require personalised proof of efficacy and treatment response predictors.

Identifiants

DOI: 10.1183/16000617.0137-2019 PMID: 32499305 PMC: PMC9488652
pubmed: 32499305
pii: 29/156/190137
doi: 10.1183/16000617.0137-2019
pmc: PMC9488652
pii:
doi:

Substances chimiques

Anti-Asthmatic Agents 0
Biomarkers 0
Inflammation Mediators 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright ©ERS 2020.

Déclaration de conflit d'intérêts

Conflict of interest: M. Bonini has nothing to disclose. Conflict of interest: M. Di Paolo has nothing to disclose. Conflict of interest: D. Bagnasco has nothing to disclose. Conflict of interest: I. Baiardini has nothing to disclose. Conflict of interest: F. Braido has nothing to disclose. Conflict of interest: M. Caminati has nothing to disclose. Conflict of interest: E. Carpagnano has nothing to disclose. Conflict of interest: M. Contoli reports grants from Chiesi, personal fees from Chiesi, AstraZeneca, Boehringer Ingelheim, Novartis Menarini, Mundipharma, Almirall and Zambon, and grants from University of Ferrara (Italy), outside the submitted work. Conflict of interest: A. Corsico has nothing to disclose. Conflict of interest: S. Del Giacco has nothing to disclose. Conflict of interest: E. Heffler has nothing to disclose. Conflict of interest: C. Lombardi has nothing to disclose. Conflict of interest: I. Menichini has nothing to disclose. Conflict of interest: M. Milanese has nothing to disclose. Conflict of interest: N. Scichilone has nothing to disclose. Conflict of interest: G. Senna has nothing to disclose. Conflict of interest: G.W. Canonica has nothing to disclose.

Références

Lancet Respir Med. 2014 Nov;2(11):879-890
pubmed: 25306557
JAMA. 2014 Oct 1;312(13):1342-3
pubmed: 25268441
Respir Med. 2016 Jul;116:19-27
pubmed: 27296816
J Allergy Clin Immunol. 1998 Jul;102(1):16-7
pubmed: 9679842
Eur Respir J. 2008 Mar;31(3):539-46
pubmed: 18057062
Eur Respir J. 2014 Dec;44(6):1428-46
pubmed: 25359355
Eur Respir J. 2015 Dec;46(6):1598-604
pubmed: 26493797
J Clin Epidemiol. 2008 Feb;61(2):102-9
pubmed: 18177782
Allergy. 2004 May;59(5):469-78
pubmed: 15080825
Lancet. 1976 Apr 24;1(7965):882-4
pubmed: 58147
Lancet Respir Med. 2019 May;7(5):402-416
pubmed: 30876830
J Man Manip Ther. 2008;16(4):E82-3
pubmed: 19771185
Am J Respir Crit Care Med. 1995 Aug;152(2):800-3
pubmed: 7633745
J Allergy Clin Immunol. 2004 Jan;113(1):59-65
pubmed: 14713908
Ann Allergy Asthma Immunol. 2009 Jun;102(6):455-61
pubmed: 19558002
J Allergy Clin Immunol. 2014 Jun;133(6):1599-605.e2
pubmed: 24290276
J Rehabil Med. 2008 Aug;40(8):615-9
pubmed: 19020694
Thorax. 1992 Jun;47(6):410-3
pubmed: 1496497
J Eval Clin Pract. 2000 Feb;6(1):39-49
pubmed: 10807023
Eur Respir J. 1999 Jul;14(1):23-7
pubmed: 10489824
J Allergy Clin Immunol. 2012 Mar;129(3 Suppl):S9-23
pubmed: 22386512
Eur Respir J. 2013 Jan;41(1):12-7
pubmed: 22653766
J Allergy Clin Immunol. 2009 Oct;124(4):719-23.e1
pubmed: 19767070
J Allergy Clin Immunol Pract. 2017 Sep - Oct;5(5):1335-1343.e5
pubmed: 28389300
Qual Life Res. 2005 Mar;14(2):285-95
pubmed: 15892420
Allergy. 2007 Feb;62(2):207-8
pubmed: 17298431
Lancet. 2012 Dec 15;380(9859):2163-96
pubmed: 23245607
Respir Med. 2005 May;99(5):553-8
pubmed: 15823451
Allergy. 2016 Oct;71(10):1472-9
pubmed: 27113353
Chest. 2001 Jan;119(1):256-70
pubmed: 11157613
Chest. 1981 Jul;80(1):97-9
pubmed: 7249720
Lancet. 2003 Mar 29;361(9363):1071-6
pubmed: 12672309
Eur J Clin Invest. 2011 Apr;41(4):411-6
pubmed: 21114492
Allergy. 2016 Jan;71(1):108-14
pubmed: 26466328
Arthritis Rheum. 2008 Apr 15;59(4):465-73
pubmed: 18383406
Am J Respir Crit Care Med. 1995 Mar;151(3 Pt 1):675-81
pubmed: 7881655
Am J Respir Crit Care Med. 1997 Apr;155(4):1278-82
pubmed: 9105067
N Engl J Med. 2014 Sep 25;371(13):1198-207
pubmed: 25199059
J Rheumatol. 2001 Feb;28(2):406-12
pubmed: 11246688
Eur Respir J. 2005 Nov;26(5):948-68
pubmed: 16264058
Eur Respir J. 1999 Oct;14(4):902-7
pubmed: 10573240
Eur Respir J. 1997 Mar;10(3):646-51
pubmed: 9072999
Control Clin Trials. 1989 Dec;10(4):407-15
pubmed: 2691207
Am J Respir Crit Care Med. 2002 Jul 1;166(1):111-7
pubmed: 12091180
Chest. 2009 Jul;136(1):155-162
pubmed: 19225065
Qual Life Res. 1993 Jun;2(3):221-6
pubmed: 8401458
Eur Respir J. 2013 Oct;42(4):1003-11
pubmed: 23349443
Ann Allergy Asthma Immunol. 2017 Nov;119(5):460-462
pubmed: 28941707
Ann Allergy Asthma Immunol. 2014 Jul;113(1):19-24
pubmed: 24846699
Eur Respir J. 2013 Oct;42(4):891-2
pubmed: 24081755
Am J Respir Crit Care Med. 2013 Dec 15;188(12):1407-12
pubmed: 24228710
N Engl J Med. 2011 Sep 22;365(12):1088-98
pubmed: 21812663
Chest. 2016 Oct;150(4):799-810
pubmed: 27018175
Respir Res. 2015 Nov 17;16:142
pubmed: 26576744
Spine J. 2007 Sep-Oct;7(5):541-6
pubmed: 17448732
Asthma Res Pract. 2017 Jan 6;3:1
pubmed: 28078100
Am J Respir Crit Care Med. 2011 Sep 1;184(5):602-15
pubmed: 21885636
Chest. 1998 Oct;114(4):998-1007
pubmed: 9792568
COPD. 2005 Mar;2(1):75-9
pubmed: 17136966
Lancet Respir Med. 2013 Mar;1(1):23-31
pubmed: 24321801
J Clin Epidemiol. 2004 Nov;57(11):1153-60
pubmed: 15567631
Allergy. 2009 Nov;64(11):1563-9
pubmed: 19712119
Eur Respir J. 2002 Jun;19(6):1015-9
pubmed: 12108850
Spine (Phila Pa 1976). 2010 Sep 1;35(19):1739-43
pubmed: 20700084
J Appl Physiol (1985). 2008 Feb;104(2):394-403
pubmed: 17991792
Eur Respir J. 2014 Dec;44(6):1447-78
pubmed: 25359356
Lancet. 2016 Oct 29;388(10056):2115-2127
pubmed: 27609408
Am J Respir Crit Care Med. 2016 May 1;193(9):949-56
pubmed: 26756066
Lancet. 2018 Feb 24;391(10122):783-800
pubmed: 29273246
Eur J Intern Med. 2017 Mar;38:12-16
pubmed: 27939043
Expert Rev Respir Med. 2020 Feb;14(2):163-172
pubmed: 31899999
Lancet Respir Med. 2015 Nov;3(11):849-58
pubmed: 26493938
J Allergy Clin Immunol. 2013 Jul;132(1):72-80
pubmed: 23706399
Eur Respir J. 2009 Sep;34(3):568-73
pubmed: 19720808
Respir Med. 2002 Nov;96(11):895-900
pubmed: 12418587
J Allergy Clin Immunol. 2000 Nov;106(5):861-6
pubmed: 11080707
Chest. 1977 Aug;72(2):154-8
pubmed: 884975
Prim Care Respir J. 2013 Sep;22(3):284-9
pubmed: 23616053
Eur Respir J. 2016 Feb;47(2):429-60
pubmed: 26797036
Lancet. 2016 Oct 29;388(10056):2128-2141
pubmed: 27609406
Curr Opin Allergy Clin Immunol. 2018 Apr;18(2):96-108
pubmed: 29389730
J Clin Epidemiol. 2009 Apr;62(4):374-9
pubmed: 19013766
Am J Respir Crit Care Med. 2009 Jul 1;180(1):59-99
pubmed: 19535666
Am J Respir Crit Care Med. 1998 Nov;158(5 Pt 1):1384-7
pubmed: 9817683
Lancet. 2006 Aug 26;368(9537):744-53
pubmed: 16935685
Med Care. 2003 May;41(5):582-92
pubmed: 12719681
Eur Respir J. 2010 Dec;36(6):1410-6
pubmed: 20530041
Clin Orthop Relat Res. 2017 Apr;475(4):929-932
pubmed: 28124297
Respir Med. 2013 Oct;107(10):1491-500
pubmed: 23972381
J Man Manip Ther. 2012 Aug;20(3):160-6
pubmed: 23904756
J Allergy Clin Immunol. 2012 Nov;130(5):1078-84
pubmed: 23026499
Health Qual Life Outcomes. 2006 Sep 27;4:70
pubmed: 17005038
Allergy. 2010 Feb;65(2):141-51
pubmed: 19909298
Allergy. 2009 Dec;64(12):1780-7
pubmed: 19627273
J Allergy Clin Immunol. 2007 Apr;119(4):817-25
pubmed: 17353040
Eur Respir J. 2007 Jan;29(1):185-209
pubmed: 17197484
J Allergy Clin Immunol. 2005 Jun;115(6):1130-6
pubmed: 15940124
Am J Respir Crit Care Med. 2001 Sep 1;164(5):738-43
pubmed: 11549525
Chest. 2016 Oct;150(4):789-798
pubmed: 27056586
Pediatr Allergy Immunol. 2006 May;17(3):189-93
pubmed: 16672005
J Allergy Clin Immunol. 2012 Mar;129(3 Suppl):S124-35
pubmed: 22386505
Eur Respir J Suppl. 2002 Sep;37:47s-50s
pubmed: 12361364

Auteurs

Matteo Bonini (M)

National Heart and Lung Institute, Royal Brompton Hospital & Imperial College London, London, UK.
UOC Pneumologia, Istituto di Medicina Interna, F. Policlinico Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Marcello Di Paolo (M)

National Heart and Lung Institute, Royal Brompton Hospital & Imperial College London, London, UK.
ORCID: 0000-0001-9123-1389

Diego Bagnasco (D)

Allergy and Respiratory diseases, University of Genoa, Dept of Internal Medicine (DiMI), Ospedale Policlinico San Martino, Genoa, Italy.

Ilaria Baiardini (I)

Dept of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

Fulvio Braido (F)

Allergy and Respiratory diseases, University of Genoa, Dept of Internal Medicine (DiMI), Ospedale Policlinico San Martino, Genoa, Italy.

Marco Caminati (M)

Dept of Medicine, University of Verona, Verona, Italy.
Asthma Center and Allergy Unit, Verona University Hospital, Verona, Italy.

Elisiana Carpagnano (E)

Division of Respiratory Diseases, Dept of Medical and Surgical Sciences, University of Foggia, Italy.

Marco Contoli (M)

Section of Internal and Cardiorespiratory Medicine, Dept of Medical Sciences, University of Ferrara, Ferrara, Italy.

Angelo Corsico (A)

Division of Respiratory Diseases, IRCCS Policlinico San Matteo Foundation - Dept of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.

Stefano Del Giacco (S)

Dept of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
ORCID: 0000-0002-4517-1749

Enrico Heffler (E)

Personalized Medicine, Asthma and Allergy - Humanitas Research Hospital, Rozzano, Italy.

Carlo Lombardi (C)

Departmental Unit of Pneumology & Allergology, Istituto Ospedaliero Fondazione Poliambulanza, Brescia, Italy.

Ilaria Menichini (I)

Dept of Cardiovascular, Respiratory, Nephrology, Anaesthesiology and Geriatric Science, "Sapienza" University, Rome, Italy.

Manlio Milanese (M)

Division of Pulmonology, S Corona Hospital, Savona, Italy.

Nicola Scichilone (N)

AOUP Policlinico Universitario, DIBIMIS, Università di Palermo, Palermo, Italy.
ORCID: 0000-0001-6400-6573

Gianenrico Senna (G)

Dept of Medicine, University of Verona, Verona, Italy.
Asthma Center and Allergy Unit, Verona University Hospital, Verona, Italy.

Giorgio W Canonica (GW)

Personalized Medicine, Asthma and Allergy - Humanitas Research Hospital, Rozzano, Italy.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents de l'appareil respiratoire › Antiasthmatiques › Minimal clinically important difference for...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Minimal clinically important difference for...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Minimal clinically important difference for...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques respiratoires › Respiration › Mécanique respiratoire › Bronchoconstriction › Minimal clinically important difference for...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Pensée (activité mentale) › Prise de décision › Consensus › Minimal clinically important difference for...
questionsmedicales.fr › Sciences de l'information › Analyse des systèmes › Méthode Delphi › Minimal clinically important difference for...
questionsmedicales.fr › Techniques d'investigation › Détermination du point final › Minimal clinically important difference for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Minimal clinically important difference for...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Minimal clinically important difference for...
questionsmedicales.fr › Appareil respiratoire › Poumon › Minimal clinically important difference for...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Évaluation des résultats des patients › Pertinence clinique › Différence minimale cliniquement importante › Minimal clinically important difference for...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Valeur prédictive des tests › Minimal clinically important difference for...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Évaluation des symptômes › Minimal clinically important difference for...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Minimal clinically important difference for...