Notch signalling drives synovial fibroblast identity and arthritis pathology.

Animals Arthritis, Rheumatoid / genetics Endothelial Cells / pathology Fibroblasts / metabolism Humans Inflammation / metabolism Male Mice Receptor, Notch3 / antagonists & inhibitors Signal Transduction Synovial Membrane / pathology Thy-1 Antigens / metabolism

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
06 2020
Historique:
received: 11 02 2019
accepted: 26 02 2020
pubmed: 6 6 2020
medline: 10 7 2020
entrez: 6 6 2020
Statut: ppublish

Résumé

The synovium is a mesenchymal tissue composed mainly of fibroblasts, with a lining and sublining that surround the joints. In rheumatoid arthritis the synovial tissue undergoes marked hyperplasia, becomes inflamed and invasive, and destroys the joint

Identifiants

DOI: 10.1038/s41586-020-2222-z PMID: 32499639 PMC: PMC7841716
pubmed: 32499639
doi: 10.1038/s41586-020-2222-z
pii: 10.1038/s41586-020-2222-z
pmc: PMC7841716
mid: NIHMS1567478
doi:

Substances chimiques

Receptor, Notch3 0
Thy-1 Antigens 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

259-264

Subventions

Organisme : NIAMS NIH HHS
ID : R01 AR046713
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR002542
Pays : United States
Organisme : Medical Research Council
ID : MR/S025308/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT104551MA
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S035850/1
Pays : United Kingdom
Organisme : NIAMS NIH HHS
ID : R01 AR063759
Pays : United States
Organisme : NIAMS NIH HHS
ID : K08 AR077037
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067691
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR007530
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR073833
Pays : United States
Organisme : NHGRI NIH HHS
ID : U01 HG009379
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR063709
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR067677
Pays : United States
Organisme : Medical Research Council
ID : MR/R013926/1
Pays : United Kingdom
Organisme : NIAMS NIH HHS
ID : UH2 AR067694
Pays : United States
Organisme : Medical Research Council
ID : G116/131
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0800648
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI148435
Pays : United States
Organisme : NIH HHS
ID : T32 AR007530-31
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR075423
Pays : United States

Investigateurs

Jennifer Albrecht (J)
Jennifer H Anolik (JH)
William Apruzzese (W)
Brendan F Boyce (BF)
David L Boyle (DL)
S Louis Bridges (SL)
Jane H Buckner (JH)
Vivian P Bykerk (VP)
Edward DiCarlo (E)
James Dolan (J)
Thomas M Eisenhaure (TM)
Gary S Firestein (GS)
Chamith Y Fonseka (CY)
Susan M Goodman (SM)
Ellen M Gravallese (EM)
Peter K Gregersen (PK)
Joel M Guthridge (JM)
Maria Gutierrez-Arcelus (M)
Nir Hacohen (N)
V Michael Holers (VM)
Laura B Hughes (LB)
Lionel B Ivashkiv (LB)
Eddie A James (EA)
Judith A James (JA)
A Helena Jonsson (AH)
Josh Keegan (J)
Stephen Kelly (S)
Yvonne C Lee (YC)
James A Lederer (JA)
David J Lieb (DJ)
Arthur M Mandelin (AM)
Mandy J McGeachy (MJ)
Michael A McNamara (MA)
Joseph R Mears (JR)
Nida Meednu (N)
Fumitaka Mizoguchi (F)
Larry Moreland (L)
Jennifer P Nguyen (JP)
Chad Nusbaum (C)
Akiko Noma (A)
Dana E Orange (DE)
Harris Perlman (H)
Costantino Pitzalis (C)
Javier Rangel-Moreno (J)
Deepak A Rao (DA)
Mina Rohani-Pichavant (M)
Christopher Ritchlin (C)
William H Robinson (WH)
Karen Salomon-Escoto (K)
Anupamaa Seshadri (A)
Jennifer Seifert (J)
Kamil Slowikowski (K)
Danielle Sutherby (D)
Darren Tabechian (D)
Jason D Turner (JD)
Paul J Utz (PJ)
Fan Zhang (F)

Commentaires et corrections

Type : CommentIn
Type : CommentIn

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Auteurs

Kevin Wei (K)

Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Ilya Korsunsky (I)

Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Jennifer L Marshall (JL)

Rheumatology Research Group, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.

Anqi Gao (A)

Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Gerald F M Watts (GFM)

Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Triin Major (T)

Rheumatology Research Group, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.
ORCID: 0000-0003-3787-6068

Adam P Croft (AP)

Rheumatology Research Group, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.
ORCID: 0000-0002-9487-0511

Jordan Watts (J)

Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Philip E Blazar (PE)

Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, MA, USA.

Jeffrey K Lange (JK)

Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, MA, USA.

Thomas S Thornhill (TS)

Department of Orthopedic Surgery, Brigham and Women's Hospital, Boston, MA, USA.

Andrew Filer (A)

Rheumatology Research Group, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.
ORCID: 0000-0001-8164-6249

Karim Raza (K)

Rheumatology Research Group, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.

Laura T Donlin (LT)

Arthritis and Tissue Degeneration, Hospital for Special Surgery, New York, NY, USA.
ORCID: 0000-0002-1428-090X

Christian W Siebel (CW)

Department of Discovery Oncology, Genentech, South San Francisco, CA, USA.

Christopher D Buckley (CD)

Rheumatology Research Group, Institute for Inflammation and Ageing, NIHR Birmingham Biomedical Research Center and Clinical Research Facility, University of Birmingham, Queen Elizabeth Hospital, Birmingham, UK.
The Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
ORCID: 0000-0001-6924-6402

Soumya Raychaudhuri (S)

Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.
Center for Data Sciences, Brigham and Women's Hospital, Boston, MA, USA. soumya@broadinstitute.org.
Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. soumya@broadinstitute.org.
Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. soumya@broadinstitute.org.
Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK. soumya@broadinstitute.org.
ORCID: 0000-0002-1901-8265

Michael B Brenner (MB)

Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. mbrenner@research.bwh.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Notch signalling drives synovial fibroblast...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Polyarthrite rhumatoïde › Notch signalling drives synovial fibroblast...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Notch signalling drives synovial fibroblast...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Notch signalling drives synovial fibroblast...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Notch signalling drives synovial fibroblast...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Notch signalling drives synovial fibroblast...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Notch signalling drives synovial fibroblast...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs Notch › Récepteur Notch3 › Notch signalling drives synovial fibroblast...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Notch signalling drives synovial fibroblast...
questionsmedicales.fr › Appareil locomoteur › Squelette › Articulations › Capsule articulaire › Membrane synoviale › Notch signalling drives synovial fibroblast...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigènes Thy-1 › Notch signalling drives synovial fibroblast...