A calcineurin-Hoxb13 axis regulates growth mode of mammalian cardiomyocytes.
Animals
Animals, Newborn
Calcineurin
/ metabolism
Cell Proliferation
Female
Gene Deletion
Gene Expression Regulation
Heart
/ physiology
Homeodomain Proteins
/ genetics
Male
Mice
Myeloid Ecotropic Viral Integration Site 1 Protein
/ metabolism
Myocardium
/ cytology
Myocytes, Cardiac
/ cytology
Protein Binding
Regeneration
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
02
12
2018
accepted:
24
02
2020
pubmed:
6
6
2020
medline:
10
7
2020
entrez:
6
6
2020
Statut:
ppublish
Résumé
A major factor in the progression to heart failure in humans is the inability of the adult heart to repair itself after injury. We recently demonstrated that the early postnatal mammalian heart is capable of regeneration following injury through proliferation of preexisting cardiomyocytes
Identifiants
pubmed: 32499640
doi: 10.1038/s41586-020-2228-6
pii: 10.1038/s41586-020-2228-6
pmc: PMC7670845
mid: NIHMS1566238
doi:
Substances chimiques
Homeodomain Proteins
0
Hoxb13 protein, mouse
0
Meis1 protein, mouse
0
Myeloid Ecotropic Viral Integration Site 1 Protein
0
Calcineurin
EC 3.1.3.16
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
271-276Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM136243
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL147276
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM119336
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL126012
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL115275
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL131778
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128215
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL125247
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD101006
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD087351
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL120732
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD087351
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL072016
Pays : United States
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