Identification of type 2 diabetes loci in 433,540 East Asian individuals.

Aldehyde Dehydrogenase, Mitochondrial / genetics Alleles Ankyrins / genetics Asian People / genetics Body Mass Index Case-Control Studies Diabetes Mellitus, Type 2 / genetics Europe / ethnology Eye Proteins / genetics Asia, Eastern / ethnology Female Genetic Predisposition to Disease Genome-Wide Association Study Homeodomain Proteins / genetics Humans Male Nerve Tissue Proteins / genetics RNA, Messenger / analysis Transcription Factors / genetics Transcription, Genetic Homeobox Protein SIX3

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
06 2020
Historique:
received: 24 06 2019
accepted: 02 03 2020
pubmed: 6 6 2020
medline: 10 7 2020
entrez: 6 6 2020
Statut: ppublish

Résumé

Meta-analyses of genome-wide association studies (GWAS) have identified more than 240 loci that are associated with type 2 diabetes (T2D)

Identifiants

DOI: 10.1038/s41586-020-2263-3 PMID: 32499647 PMC: PMC7292783
pubmed: 32499647
doi: 10.1038/s41586-020-2263-3
pii: 10.1038/s41586-020-2263-3
pmc: PMC7292783
mid: NIHMS1570876
doi:

Substances chimiques

ANK1 protein, human 0
Ankyrins 0
Eye Proteins 0
GDAP protein 0
Homeodomain Proteins 0
Nerve Tissue Proteins 0
Nkx6-3 protein, human 0
RNA, Messenger 0
Transcription Factors 0
transcription factor PTF1 0
ALDH2 protein, human EC 1.2.1.3
Aldehyde Dehydrogenase, Mitochondrial EC 1.2.1.3

Types de publication

Journal Article Meta-Analysis Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

240-245

Subventions

Organisme : NHLBI NIH HHS
ID : N01HC95160
Pays : United States
Organisme : Wellcome Trust
ID : 212946/Z/18/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12026/2
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : N01HC95169
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK072193
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95164
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00017/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U137686851
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK078150
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK093757
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK080720
Pays : United States
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ID : UL1 TR001079
Pays : United States
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ID : R01 HD030880
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK105556
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA144034
Pays : United States
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ID : R01 HL142302
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ID : R01 DK104371
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ID : N01HC95162
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Pays : United States
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Organisme : NIDDK NIH HHS
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Pays : United States
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Pays : United States
Organisme : Wellcome Trust
ID : 200837/Z/16/Z
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : UM1 CA182910
Pays : United States
Organisme : FIC NIH HHS
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Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR003098
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA182876
Pays : United States

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Auteurs

Cassandra N Spracklen (CN)

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA, USA.
ORCID: 0000-0003-3590-7182

Momoko Horikoshi (M)

Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan.

Young Jin Kim (YJ)

Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Republic of Korea.
ORCID: 0000-0002-4132-4437

Kuang Lin (K)

Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Fiona Bragg (F)

Nuffield Department of Population Health, University of Oxford, Oxford, UK.
ORCID: 0000-0002-9181-6886

Sanghoon Moon (S)

Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Republic of Korea.

Ken Suzuki (K)

Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan.
Laboratory for Statistical and Translational Genetics, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan.
Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.

Claudia H T Tam (CHT)

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong Kong, Hong Kong, China.
ORCID: 0000-0002-9169-0013

Yasuharu Tabara (Y)

Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Soo-Heon Kwak (SH)

Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.

Fumihiko Takeuchi (F)

Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
ORCID: 0000-0003-3185-5661

Jirong Long (J)

Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Victor J Y Lim (VJY)

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.

Jin-Fang Chai (JF)

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
ORCID: 0000-0003-3770-1137

Chien-Hsiun Chen (CH)

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

Masahiro Nakatochi (M)

Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.
ORCID: 0000-0002-1838-4837

Jie Yao (J)

The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Department of Pediatrics, UCLA School of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.

Hyeok Sun Choi (HS)

Biomedical Science, Hallym University, Chuncheon, South Korea.

Apoorva K Iyengar (AK)

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Hannah J Perrin (HJ)

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Sarah M Brotman (SM)

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
ORCID: 0000-0002-7566-8895

Martijn van de Bunt (M)

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.

Anna L Gloyn (AL)

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford, UK.
Stanford University, Stanford, CA, USA.
ORCID: 0000-0003-1205-1844

Jennifer E Below (JE)

Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Michael Boehnke (M)

Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0002-6442-7754

Donald W Bowden (DW)

Center for Genomics and Personalized Medicine Research, Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.

John C Chambers (JC)

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, London, UK.
Imperial College Healthcare NHS Trust, Imperial College London, London, UK.
MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.

Anubha Mahajan (A)

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Genentech, South San Francisco, CA, USA.
ORCID: 0000-0001-5585-3420

Mark I McCarthy (MI)

Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Oxford NIHR Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Churchill Hospital, Oxford, UK.
Genentech, South San Francisco, CA, USA.
ORCID: 0000-0002-4393-0510

Maggie C Y Ng (MCY)

Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Center for Genomics and Personalized Medicine Research, Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.
ORCID: 0000-0002-4133-2007

Lauren E Petty (LE)

Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Weihua Zhang (W)

Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, London, UK.

Andrew P Morris (AP)

Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Department of Biostatistics, University of Liverpool, Liverpool, UK.
School of Biological Sciences, University of Manchester, Manchester, UK.

Linda S Adair (LS)

Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Masato Akiyama (M)

Laboratory for Statistical and Translational Genetics, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan.
Laboratory for Statistical Analysis, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan.
Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Zheng Bian (Z)

Chinese Academy of Medical Sciences, Beijing, China.

Juliana C N Chan (JCN)

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China.
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.

Li-Ching Chang (LC)

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

Miao-Li Chee (ML)

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.

Yii-Der Ida Chen (YI)

The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Department of Pediatrics, UCLA School of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.

Yuan-Tsong Chen (YT)

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

Zhengming Chen (Z)

Nuffield Department of Population Health, University of Oxford, Oxford, UK.
ORCID: 0000-0001-6423-105X

Lee-Ming Chuang (LM)

Division of Endocrinology & Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Institute of Preventive Medicine, School of Public Health, National Taiwan University, Taipei, Taiwan.

Shufa Du (S)

Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Penny Gordon-Larsen (P)

Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Myron Gross (M)

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.

Xiuqing Guo (X)

The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Department of Pediatrics, UCLA School of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.

Yu Guo (Y)

Chinese Academy of Medical Sciences, Beijing, China.

Sohee Han (S)

Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Republic of Korea.
ORCID: 0000-0003-2181-2131

Annie-Green Howard (AG)

Department of Biostatistics, Carolina Population Center, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Wei Huang (W)

Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China.

Yi-Jen Hung (YJ)

Division of Endocrine and Metabolism, Tri-Service General Hospital Songshan Branch, Taipei, Taiwan.
School of Medicine, National Defense Medical Center, Taipei, Taiwan.

Mi Yeong Hwang (MY)

Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Republic of Korea.

Chii-Min Hwu (CM)

Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.
School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Sahoko Ichihara (S)

Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan.

Masato Isono (M)

Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.

Hye-Mi Jang (HM)

Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Republic of Korea.

Guozhi Jiang (G)

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Jost B Jonas (JB)

Department of Ophthalmology, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany.
ORCID: 0000-0003-2972-5227

Yoichiro Kamatani (Y)

Laboratory for Statistical and Translational Genetics, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan.
Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
ORCID: 0000-0001-8748-5597

Tomohiro Katsuya (T)

Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Osaka, Japan.
Department of Geriatric and General Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.

Takahisa Kawaguchi (T)

Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Chiea-Chuen Khor (CC)

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
ORCID: 0000-0002-1128-4729

Katsuhiko Kohara (K)

Department of Regional Resource Management, Ehime University Faculty of Collaborative Regional Innovation, Ehime, Japan.

Myung-Shik Lee (MS)

Severance Biomedical Science Institute and Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
ORCID: 0000-0003-3292-1720

Nanette R Lee (NR)

Department of Anthropology, Sociology and History, University of San Carlos, Cebu City, Philippines.

Liming Li (L)

Department of Epidemiology and Biostatistics, Peking University Health Science Centre, Peking University, Beijing, China.

Jianjun Liu (J)

Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
ORCID: 0000-0002-3255-3019

Andrea O Luk (AO)

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Jun Lv (J)

Department of Epidemiology and Biostatistics, Peking University Health Science Centre, Peking University, Beijing, China.

Yukinori Okada (Y)

Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.
Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Osaka, Japan.
ORCID: 0000-0002-0311-8472

Mark A Pereira (MA)

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.

Charumathi Sabanayagam (C)

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.
Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
ORCID: 0000-0002-4042-4719

Jinxiu Shi (J)

Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.

Dong Mun Shin (DM)

Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Republic of Korea.

Wing Yee So (WY)

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China.

Atsushi Takahashi (A)

Laboratory for Statistical and Translational Genetics, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan.
Department of Genomic Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.
ORCID: 0000-0001-7099-8767

Brian Tomlinson (B)

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Faculty of Medicine, Macau University of Science and Technology, Macau, China.
ORCID: 0000-0001-6717-5444

Fuu-Jen Tsai (FJ)

Department of Medical Genetics and Medical Research, China Medical University Hospital, Taichung, Taiwan.
ORCID: 0000-0002-1373-245X

Rob M van Dam (RM)

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.

Yong-Bing Xiang (YB)

State Key Laboratory of Oncogene and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Ken Yamamoto (K)

Department of Medical Biochemistry, Kurume University School of Medicine, Kurume, Japan.
ORCID: 0000-0002-1531-9685

Toshimasa Yamauchi (T)

Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
ORCID: 0000-0003-4827-6404

Kyungheon Yoon (K)

Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Republic of Korea.

Canqing Yu (C)

Department of Epidemiology and Biostatistics, Peking University Health Science Centre, Peking University, Beijing, China.

Jian-Min Yuan (JM)

Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
ORCID: 0000-0002-4620-3108

Liang Zhang (L)

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
ORCID: 0000-0001-9264-170X

Wei Zheng (W)

Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
ORCID: 0000-0003-1226-070X

Michiya Igase (M)

Department of Anti-aging Medicine, Ehime University Graduate School of Medicine, Ehime, Japan.
ORCID: 0000-0003-2545-4124

Yoon Shin Cho (YS)

Biomedical Science, Hallym University, Chuncheon, South Korea.

Jerome I Rotter (JI)

The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Department of Pediatrics, UCLA School of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.
ORCID: 0000-0001-7191-1723

Ya-Xing Wang (YX)

Beijing Institute of Ophthalmology, Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
ORCID: 0000-0003-2749-7793

Wayne H H Sheu (WHH)

School of Medicine, National Defense Medical Center, Taipei, Taiwan.
School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

Mitsuhiro Yokota (M)

Kurume University School of Medicine, Kurume, Japan.

Jer-Yuarn Wu (JY)

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

Ching-Yu Cheng (CY)

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.
Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
ORCID: 0000-0003-0655-885X

Tien-Yin Wong (TY)

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.
Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.

Xiao-Ou Shu (XO)

Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Norihiro Kato (N)

Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.

Kyong-Soo Park (KS)

Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea.
ORCID: 0000-0003-3597-342X

E-Shyong Tai (ES)

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
Duke-NUS Medical School, Singapore, Singapore.

Fumihiko Matsuda (F)

Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Woon-Puay Koh (WP)

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore.

Ronald C W Ma (RCW)

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.
Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China.
Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.
ORCID: 0000-0002-1227-803X

Shiro Maeda (S)

Laboratory for Endocrinology, Metabolism and Kidney Diseases, RIKEN Centre for Integrative Medical Sciences, Yokohama, Japan.
Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, Okinawa, Japan.

Iona Y Millwood (IY)

Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK.

Juyoung Lee (J)

Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Republic of Korea.

Takashi Kadowaki (T)

Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. kadowaki-3im@h.u-tokyo.ac.jp.
ORCID: 0000-0002-5428-3582

Robin G Walters (RG)

Nuffield Department of Population Health, University of Oxford, Oxford, UK. robin.walters@ndph.ox.ac.uk.
Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK. robin.walters@ndph.ox.ac.uk.
ORCID: 0000-0002-9179-0321

Bong-Jo Kim (BJ)

Division of Genome Research, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Republic of Korea. kbj6181@korea.kr.

Karen L Mohlke (KL)

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. mohlke@med.unc.edu.
ORCID: 0000-0001-6721-153X

Xueling Sim (X)

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore. ephsx@nus.edu.sg.
ORCID: 0000-0002-1233-7642

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Aldehyde dehydrogenase, mitochondrial › Identification of type 2 diabetes loci in...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Allèles › Identification of type 2 diabetes loci in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Ankyrines › Identification of type 2 diabetes loci in...
questionsmedicales.fr › Personnes › Asiatiques › Identification of type 2 diabetes loci in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Biométrie › Anthropométrie › Indice de masse corporelle › Identification of type 2 diabetes loci in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Identification of type 2 diabetes loci in...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Identification of type 2 diabetes loci in...
questionsmedicales.fr › Régions géographiques › Europe › Identification of type 2 diabetes loci in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de l'oeil › Identification of type 2 diabetes loci in...
questionsmedicales.fr › Régions géographiques › Asie › Extrême-Orient › Identification of type 2 diabetes loci in...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Identification of type 2 diabetes loci in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Identification of type 2 diabetes loci in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Protéines à homéodomaine › Identification of type 2 diabetes loci in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identification of type 2 diabetes loci in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Identification of type 2 diabetes loci in...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Identification of type 2 diabetes loci in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Identification of type 2 diabetes loci in...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › Identification of type 2 diabetes loci in...