Molecular design of hypothalamus development.

Animals Cell Differentiation Cell Lineage Dopamine / metabolism Dopaminergic Neurons / cytology Ectoderm / cytology Female GABAergic Neurons / cytology Gene Expression Regulation, Developmental Gene Regulatory Networks Genome-Wide Association Study Glutamic Acid / metabolism Hypothalamus / cytology Male Mice Morphogenesis / genetics Nerve Tissue Proteins / metabolism Neuroglia / cytology Neuropeptides / metabolism Neurotransmitter Agents / metabolism Receptors, Immunologic / metabolism Regulon / genetics Signal Transduction Transcription Factors / metabolism gamma-Aminobutyric Acid / metabolism Roundabout Proteins

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
06 2020
Historique:
received: 09 06 2019
accepted: 05 03 2020
pubmed: 6 6 2020
medline: 10 7 2020
entrez: 6 6 2020
Statut: ppublish

Résumé

A wealth of specialized neuroendocrine command systems intercalated within the hypothalamus control the most fundamental physiological needs in vertebrates

Identifiants

DOI: 10.1038/s41586-020-2266-0 PMID: 32499648 PMC: PMC7292733
pubmed: 32499648
doi: 10.1038/s41586-020-2266-0
pii: 10.1038/s41586-020-2266-0
pmc: PMC7292733
mid: EMS85981
doi:

Substances chimiques

Nerve Tissue Proteins 0
Neuropeptides 0
Neurotransmitter Agents 0
Receptors, Immunologic 0
Transcription Factors 0
slit protein, vertebrate 0
Glutamic Acid 3KX376GY7L
gamma-Aminobutyric Acid 56-12-2
Dopamine VTD58H1Z2X

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

246-252

Subventions

Organisme : European Research Council
ID : 695136
Pays : International
Organisme : Austrian Science Fund FWF
ID : DOC 33
Pays : Austria

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Auteurs

Roman A Romanov (RA)

Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Department of Neuroscience, Biomedicum D7, Karolinska Institutet, Solna, Sweden.
ORCID: 0000-0002-3937-518X

Evgenii O Tretiakov (EO)

Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
ORCID: 0000-0001-5920-2190

Maria Eleni Kastriti (ME)

Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Department of Physiology and Pharmacology, Biomedicum D6, Karolinska Institutet, Solna, Sweden.

Maja Zupancic (M)

Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.

Martin Häring (M)

Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.

Solomiia Korchynska (S)

Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.

Konstantin Popadin (K)

Human Genomics of Infection and Immunity, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland.
Center for Mitochondrial Functional Genomics, Institute of Living Systems, Immanuel Kant Baltic Federal University, Kaliningrad, Russia.

Marco Benevento (M)

Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.

Patrick Rebernik (P)

Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.

Francois Lallemend (F)

Department of Neuroscience, Biomedicum D7, Karolinska Institutet, Solna, Sweden.

Katsuhiko Nishimori (K)

Deptartment of Obesity and Internal Inflammation, Fukushima Medical University, Fukushima City, Japan.

Frédéric Clotman (F)

Laboratory of Neural Differentiation, Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.
ORCID: 0000-0002-0497-2195

William D Andrews (WD)

Department of Cell and Developmental Biology, University College London, London, UK.

John G Parnavelas (JG)

Department of Cell and Developmental Biology, University College London, London, UK.

Matthias Farlik (M)

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Department of Dermatology, Medical University of Vienna, Vienna, Austria.

Christoph Bock (C)

CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
ORCID: 0000-0001-6091-3088

Igor Adameyko (I)

Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Department of Physiology and Pharmacology, Biomedicum D6, Karolinska Institutet, Solna, Sweden.

Tomas Hökfelt (T)

Department of Neuroscience, Biomedicum D7, Karolinska Institutet, Solna, Sweden.

Erik Keimpema (E)

Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
ORCID: 0000-0002-7555-6762

Tibor Harkany (T)

Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria. tibor.harkany@meduniwien.ac.at.
Department of Neuroscience, Biomedicum D7, Karolinska Institutet, Solna, Sweden. tibor.harkany@meduniwien.ac.at.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Molecular design of hypothalamus development.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Molecular design of hypothalamus development.
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Lignage cellulaire › Molecular design of hypothalamus development.
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Catéchols › Catécholamines › Dopamine › Molecular design of hypothalamus development.
questionsmedicales.fr › Cellules › Neurones › Neurones dopaminergiques › Molecular design of hypothalamus development.
questionsmedicales.fr › Structures de l'embryon › Feuillets embryonnaires › Ectoderme › Molecular design of hypothalamus development.
questionsmedicales.fr › Cellules › Neurones › Neurones GABAergiques › Molecular design of hypothalamus development.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes au cours du développement › Molecular design of hypothalamus development.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Séquences d'acides nucléiques régulatrices › Réseaux de régulation génique › Molecular design of hypothalamus development.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Molecular design of hypothalamus development.
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés excitateurs › Acide glutamique › Molecular design of hypothalamus development.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Hypothalamus › Molecular design of hypothalamus development.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Molecular design of hypothalamus development.
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Molecular design of hypothalamus development.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Molecular design of hypothalamus development.
questionsmedicales.fr › Cellules › Névroglie › Molecular design of hypothalamus development.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Molecular design of hypothalamus development.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Molecular design of hypothalamus development.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Molecular design of hypothalamus development.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Régulon › Molecular design of hypothalamus development.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Molecular design of hypothalamus development.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Molecular design of hypothalamus development.
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › Molecular design of hypothalamus development.