Characterisation of
Ampicillin
/ therapeutic use
Anti-Bacterial Agents
/ therapeutic use
Azithromycin
/ therapeutic use
Cholera
/ drug therapy
Cross-Sectional Studies
Disease Outbreaks
/ history
Drug Resistance, Multiple
/ genetics
Drug Resistance, Multiple, Bacterial
/ genetics
Electrophoresis, Gel, Pulsed-Field
Genotype
History, 21st Century
Hospitals, Teaching
/ statistics & numerical data
Humans
Microbial Sensitivity Tests
Serotyping
Vibrio cholerae O1
/ classification
Zambia
/ epidemiology
Cholera
Lusaka province
Vibrio cholerae
multidrug resistance
Journal
The Pan African medical journal
ISSN: 1937-8688
Titre abrégé: Pan Afr Med J
Pays: Uganda
ID NLM: 101517926
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
04
2019
accepted:
29
11
2019
entrez:
6
6
2020
pubmed:
6
6
2020
medline:
15
12
2020
Statut:
epublish
Résumé
In 2009 and 2010, more than 6,000 cholera cases were recorded during these outbreaks with more than 80% of cases recorded in Lusaka province. After a five-year break, in 2016 an outbreak occurred in Lusaka, causing more than 1,000 cases of cholera. This study will strengthen the epidemiological information on the changing characteristics of the cholera outbreaks, for treatment, prevention and control of the disease. This was a laboratory-based descriptive cross-sectional study conducted at the University Teaching Hospital in Lusaka, Zambia. A total of 83 Macrorestriction analysis of the isolates demonstrated high genetic diversity among the isolates with 16 different patterns. The largest pattern comprised 9 isolates while the smallest one had 1 isolate. 2009 and 2010 isolates were highly resistant to nalidixic acid and cotrimoxazole, but highly sensitive to azithromycin and ampicillin. Of the fifty-two isolates from the 2016 cholera outbreak, 90% (47) were sensitive to cotrimoxazole, 94% (49) to tetracycline, and 98% (51) to azithromycin, while 98% (51) were resistant to nalidixic acid and 31(60%) to ampicillin. macrorestriction analysis demonstrated high genetic diversity among the
Identifiants
pubmed: 32499849
doi: 10.11604/pamj.2020.35.32.18853
pii: PAMJ-35-32
pmc: PMC7245973
doi:
Substances chimiques
Anti-Bacterial Agents
0
Ampicillin
7C782967RD
Azithromycin
83905-01-5
Types de publication
Historical Article
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
32Informations de copyright
© Kapambwe Mwape et al.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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