Disruption of the CD Loop by Enzymatic Cleavage Promotes the Formation of Toxic Transthyretin Oligomers through a Common Transthyretin Misfolding Pathway.


Journal

Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623

Informations de publication

Date de publication:
30 06 2020
Historique:
pubmed: 6 6 2020
medline: 25 2 2021
entrez: 6 6 2020
Statut: ppublish

Résumé

Amyloid formation of full-length TTR involves dissociation of the native tetramers into misfolded monomers that self-assemble into amyloid. In addition to the full-length TTR, C-terminal fragments including residues 49-127 were also observed

Identifiants

pubmed: 32500705
doi: 10.1021/acs.biochem.0c00079
pmc: PMC7339286
mid: NIHMS1605923
doi:

Substances chimiques

Amyloidogenic Proteins 0
Prealbumin 0
Trypsin EC 3.4.21.4

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

2319-2327

Subventions

Organisme : NIGMS NIH HHS
ID : P41 GM132079
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK046335
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS097490
Pays : United States
Organisme : NIH HHS
ID : S10 OD023513
Pays : United States

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Auteurs

Anvesh K R Dasari (AKR)

Department of Chemistry, East Carolina University, Greenville, North Carolina 27858, United States.

Jenette Arreola (J)

Department of Chemistry, East Carolina University, Greenville, North Carolina 27858, United States.

Brian Michael (B)

Department of Chemistry and Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

Robert G Griffin (RG)

Department of Chemistry and Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.

Jeffery W Kelly (JW)

Department of Molecular and Experimental Medicine and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, United States.

Kwang Hun Lim (KH)

Department of Chemistry, East Carolina University, Greenville, North Carolina 27858, United States.

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Classifications MeSH