Successful Surgical Treatment Combined With Infliximab in a Patient With Acute Aortic Regurgitation Caused by Behçet Disease.
Journal
The Canadian journal of cardiology
ISSN: 1916-7075
Titre abrégé: Can J Cardiol
Pays: England
ID NLM: 8510280
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
05
11
2019
revised:
13
03
2020
accepted:
18
03
2020
pubmed:
6
6
2020
medline:
19
5
2021
entrez:
6
6
2020
Statut:
ppublish
Résumé
Standard aortic valve replacement for aortic regurgitation caused by Behçet disease (BD) is frequently complicated by postoperative recurrent prosthetic valve detachment. Tumour necrosis factor (TNF) α is known to be associated with higher inflammation activities. Therefore, the concomitant use of immunomodulatory agents with TNFα inhibitors may be the key to a better outcome. This is a case report of a 46-year-old woman with severe acute aortic regurgitation due to BD. Immunosuppressive therapy including the TNFα inhibitor infliximab, which has not been reported for perioperative use to date, resulted in the prompt remission of inflammation, leading to the success of Bentall surgery.
Identifiants
pubmed: 32502427
pii: S0828-282X(20)30302-0
doi: 10.1016/j.cjca.2020.03.029
pii:
doi:
Substances chimiques
Antirheumatic Agents
0
Infliximab
B72HH48FLU
Types de publication
Case Reports
Video-Audio Media
Langues
eng
Sous-ensembles de citation
IM
Pagination
1161.e3-1161.e5Informations de copyright
Copyright © 2020 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.