Could the Heat Shock Proteins 70 Family Members Exacerbate the Immune Response in Multiple Sclerosis? An in Silico Study.
Antigens
/ genetics
Brain
/ immunology
Computer Simulation
Gene Expression Regulation
/ genetics
HSP110 Heat-Shock Proteins
/ genetics
HSP70 Heat-Shock Proteins
/ genetics
Humans
Immunity
/ genetics
Molecular Chaperones
/ genetics
Multiple Sclerosis
/ genetics
Myelin Sheath
/ genetics
Transcriptional Activation
/ genetics
brain
heat shock proteins
immune system
in silico analysis
multiple sclerosis
transcriptome
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
03 06 2020
03 06 2020
Historique:
received:
27
04
2020
revised:
27
05
2020
accepted:
01
06
2020
entrez:
7
6
2020
pubmed:
7
6
2020
medline:
20
3
2021
Statut:
epublish
Résumé
Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system. It represents one of the main causes of neurological disability in young people. In MS, the autoimmune response is directed against myelin antigens but other possible bio-molecular markers are investigated. The aim of this work was, through an in silico study, the evaluation of the transcriptional modifications between healthy subjects and MS patients in six brain areas (corpus callosum, hippocampus, internal capsule, optic chiasm, frontal and parietal cortex) in order to identify genes representative of the disease. Our results show the upregulation of the Heat Shock Proteins (HSPs)
Identifiants
pubmed: 32503176
pii: genes11060615
doi: 10.3390/genes11060615
pmc: PMC7348765
pii:
doi:
Substances chimiques
Antigens
0
HSP110 Heat-Shock Proteins
0
HSP70 Heat-Shock Proteins
0
HSPA1A protein, human
0
HSPA1B protein, human
0
HSPA4L protein, human
0
HSPA6 protein, human
0
HSPA7 protein, human
0
HSPH1 protein, human
0
Molecular Chaperones
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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