The Dual-Active Histamine H
Animals
Antioxidants
/ metabolism
Autistic Disorder
/ chemically induced
Behavior, Animal
Cerebellum
/ metabolism
Cholinesterase Inhibitors
/ pharmacology
Female
Glutathione
/ metabolism
Histamine H3 Antagonists
/ pharmacology
Kinetics
Lipid Peroxidation
Male
Maternal Exposure
Maze Learning
Mice
Mice, Inbred C57BL
Movement
Oxidative Stress
/ drug effects
Pregnancy
Pregnancy, Animal
Receptors, Histamine H3
/ metabolism
Valproic Acid
E100
VPA-induced autism-like behaviors
acetylcholine esterase inhibitor
antagonist
anxiety histamine H3R
cerebellum
mice
oxidative stress
repetitive behaviors
sociability
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
03 Jun 2020
03 Jun 2020
Historique:
received:
22
04
2020
revised:
21
05
2020
accepted:
27
05
2020
entrez:
7
6
2020
pubmed:
7
6
2020
medline:
1
4
2021
Statut:
epublish
Résumé
The histamine H3 receptor (H3R) functions as auto- and hetero-receptors, regulating the release of brain histamine (HA) and acetylcholine (ACh), respectively. The enzyme acetylcholine esterase (AChE) is involved in the metabolism of brain ACh. Both brain HA and ACh are implicated in several cognitive disorders like Alzheimer's disease, schizophrenia, anxiety, and narcolepsy, all of which are comorbid with autistic spectrum disorder (ASD). Therefore, the novel dual-active ligand E100 with high H3R antagonist affinity (hH3R:
Identifiants
pubmed: 32503208
pii: ijms21113996
doi: 10.3390/ijms21113996
pmc: PMC7312782
pii:
doi:
Substances chimiques
Antioxidants
0
Cholinesterase Inhibitors
0
Histamine H3 Antagonists
0
Receptors, Histamine H3
0
Valproic Acid
614OI1Z5WI
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : College of Medicine and Health Sciences, United Arab Emirates University
ID : 31R233, 31R244
Références
Physiol Rev. 2008 Jul;88(3):1183-241
pubmed: 18626069
J Autism Dev Disord. 2018 Sep;48(9):3086-3092
pubmed: 29654453
FASEB J. 2011 Jul;25(7):2145-55
pubmed: 21402717
Pharmacol Ther. 2004 Jul;103(1):1-20
pubmed: 15251226
Eur Neuropsychopharmacol. 2012 Sep;22(9):672-82
pubmed: 22377193
Neuropsychiatr Dis Treat. 2019 Feb 20;15:531-542
pubmed: 30863075
J Med Chem. 2011 Jan 13;54(1):26-53
pubmed: 21062081
Mol Psychiatry. 2002;7 Suppl 2:S16-7
pubmed: 12142936
Br J Pharmacol. 2012 Dec;167(7):1398-414
pubmed: 22758607
Am J Med Genet A. 2015 Apr;167A(4):715-23
pubmed: 25655306
Biol Psychiatry. 1992 Apr 15;31(8):832-40
pubmed: 1643197
Int J Neuropsychopharmacol. 2013 Feb;16(1):91-103
pubmed: 22093185
J Pharmacol Exp Ther. 2011 Jan;336(1):38-46
pubmed: 20864505
Bioorg Med Chem. 2008 Mar 15;16(6):2968-73
pubmed: 18249544
Psychopharmacology (Berl). 2009 Jun;204(2):361-73
pubmed: 19189082
Nat Rev Neurosci. 2010 Jul;11(7):490-502
pubmed: 20559336
Expert Opin Pharmacother. 2017 Apr;18(6):581-588
pubmed: 28335658
J Res Med Sci. 2017 Feb 16;22:27
pubmed: 28413424
Int Rev Neurobiol. 2006;72:245-64
pubmed: 16697302
Eur J Neurosci. 2010 Feb;31(3):544-55
pubmed: 20105240
PLoS One. 2014 Aug 18;9(8):e104927
pubmed: 25133713
Pharmacol Biochem Behav. 2002 Jun;72(3):741-50
pubmed: 12175472
Drug Des Devel Ther. 2018 Jan 19;12:179-194
pubmed: 29403264
Eur J Pharmacol. 1993 Mar 30;234(1):129-33
pubmed: 8386092
J Med Genet. 2013 Nov;50(11):760-4
pubmed: 23825391
J Pharmacol Exp Ther. 2005 Apr;313(1):176-90
pubmed: 15608077
Autism Res. 2014 Apr;7(2):273-89
pubmed: 24124122
Sci Rep. 2018 Aug 30;8(1):13077
pubmed: 30166610
Transl Psychiatry. 2017 Jan 10;7(1):e999
pubmed: 28072412
Int J Health Sci (Qassim). 2016 Oct;10(4):564-575
pubmed: 27833522
Psychopharmacology (Berl). 2014 Jan;231(2):367-77
pubmed: 23978907
Mol Pharmacol. 1999 Jun;55(6):1101-7
pubmed: 10347254
Front Neurosci. 2018 May 16;12:304
pubmed: 29867317
JAMA. 2018 Jan 2;319(1):81-82
pubmed: 29297068
Exp Neurobiol. 2015 Dec;24(4):285-300
pubmed: 26713077
PLoS One. 2015 Jan 05;10(1):e0116363
pubmed: 25560049
Autism Res Treat. 2013;2013:731935
pubmed: 24151553
Clin Psychopharmacol Neurosci. 2017 Aug 31;15(3):229-236
pubmed: 28783931
Transl Psychiatry. 2017 May 9;7(5):e1126
pubmed: 28485729
Behav Brain Res. 2002 Apr 1;131(1-2):151-61
pubmed: 11844582
Bioorg Med Chem Lett. 2016 Aug 15;26(16):4140-5
pubmed: 27445168
Transl Psychiatry. 2016 Jun 28;6(6):e844
pubmed: 27351598
Behav Brain Res. 2009 Dec 1;204(1):217-25
pubmed: 19527754
Neuropharmacology. 2016 Jul;106:56-73
pubmed: 26581501
Bioorg Med Chem. 2008 Dec 1;16(23):9911-24
pubmed: 18976927
Curr Opin Infect Dis. 2006 Jun;19(3):290-7
pubmed: 16645492
Drug Des Devel Ther. 2014 May 28;8:627-37
pubmed: 24920886
Behav Brain Res. 2016 Jan 15;297:155-64
pubmed: 26467607
Pharmazie. 2006 Mar;61(3):179-82
pubmed: 16599255
J Child Psychol Psychiatry. 2018 Jul;59(7):744-751
pubmed: 29377119
Bioorg Med Chem. 2016 Jan 15;24(2):53-72
pubmed: 26690914
J Child Neurol. 1999 Aug;14(8):547-50
pubmed: 10456769
Neuron. 2014 Aug 6;83(3):518-32
pubmed: 25102558
Neuropharmacology. 2016 Jul;106:46-55
pubmed: 26525191
Neurosci Lett. 2008 Mar 28;434(2):218-23
pubmed: 18313850
Brain Behav Immun. 2009 Jan;23(1):116-23
pubmed: 18755264
Sci Adv. 2017 Jun 21;3(6):e1603001
pubmed: 28691086
J Autism Dev Disord. 2015 Mar;45(3):805-15
pubmed: 25234483
Age Ageing. 2017 May 1;46(3):341-343
pubmed: 28338848
Dev Neurosci. 2017;39(5):355-360
pubmed: 28750400
Biochem Pharmacol. 2007 Apr 15;73(8):1157-71
pubmed: 17288995
Physiol Behav. 2016 Oct 15;165:383-91
pubmed: 27568232
Neuroscience. 1998 Feb;82(4):993-7
pubmed: 9466423
Pharmacol Rev. 2015 Jul;67(3):601-55
pubmed: 26084539
Med Hypotheses. 2017 Mar;100:64-66
pubmed: 28236851
Cerebellum Ataxias. 2014 Jun 16;1:5
pubmed: 26331029
BMC Neurosci. 2016 Aug 22;17(1):58
pubmed: 27549180
Arzneimittelforschung. 2012 May;62(5):222-9
pubmed: 22331799
J Neuropathol Exp Neurol. 1998 Jul;57(7):645-52
pubmed: 9690668
Stress. 2013 Jul;16(4):441-51
pubmed: 23194312
Mol Autism. 2017 Mar 21;8:14
pubmed: 28344757
Chem Biol Interact. 2019 Oct 1;312:108775
pubmed: 31369746
J Med Chem. 2008 Feb 14;51(3):347-72
pubmed: 18181565
Int Rev Neurobiol. 2013;112:155-77
pubmed: 24295621
Front Pharmacol. 2017 Oct 12;8:709
pubmed: 29075190
Mini Rev Med Chem. 2007 Mar;7(3):221-9
pubmed: 17346215
Arch Gen Psychiatry. 2006 Jul;63(7):786-94
pubmed: 16818868
CNS Neurosci Ther. 2014 Jul;20(7):613-23
pubmed: 24836924
J Pharmacol Exp Ther. 2003 Jun;305(3):897-908
pubmed: 12606600
J Neurosci. 1998 Feb 15;18(4):1595-601
pubmed: 9454864
Nature. 1983 Apr 28;302(5911):832-7
pubmed: 6188956
Pharmacol Biochem Behav. 2014 Nov;126:43-9
pubmed: 25240644
Nat Neurosci. 2010 Oct;13(10):1161-9
pubmed: 20877280
Brain Behav Immun. 2011 Nov;25(8):1582-91
pubmed: 21640817
Behav Brain Res. 2008 Mar 5;187(2):207-20
pubmed: 17983671
Pharmacol Biochem Behav. 2013 Apr;105:83-8
pubmed: 23402940
Sci Rep. 2017 Jan 13;7:40541
pubmed: 28084411
Behav Brain Res. 2016 Oct 1;312:415-30
pubmed: 27363923
J Vis Exp. 2013 Dec 24;(82):50978
pubmed: 24429507
Dev Sci. 2010 Jan 1;13(1):244-51
pubmed: 20121880
Molecules. 2019 Nov 14;24(22):
pubmed: 31739417
Neuropsychopharmacology. 2014 Mar;39(4):831-40
pubmed: 24096295
Acta Psychiatr Scand. 2000 Nov;102(5):321-30
pubmed: 11098802
Neuroscientist. 2003 Dec;9(6):496-507
pubmed: 14678582
Neuroscience. 2002;114(2):451-60
pubmed: 12204214
Psychopharmacology (Berl). 2015 Dec;232(23):4303-16
pubmed: 26337613
Neurosci Lett. 2014 Nov 7;583:176-81
pubmed: 25263788
Curr Pharm Des. 2015;21(26):3760-70
pubmed: 26044979
Drug Des Devel Ther. 2015 Oct 07;9:5499-510
pubmed: 26504373
Genes Brain Behav. 2003 Oct;2(5):255-67
pubmed: 14606691
Cerebellum. 2014 Feb;13(1):151-77
pubmed: 23996631