Prevalence of chronic HBV infection in pregnant woman attending antenatal care in a tertiary hospital in Mwanza, Tanzania: a cross-sectional study.
Adolescent
Adult
Cross-Sectional Studies
DNA, Viral
/ genetics
Female
Genotype
Hepatitis B Antibodies
/ blood
Hepatitis B Surface Antigens
/ blood
Hepatitis B e Antigens
/ blood
Hepatitis B virus
/ genetics
Hepatitis B, Chronic
/ diagnosis
Humans
Infant
Infant, Newborn
Male
Pregnancy
Prenatal Care
Prevalence
Tanzania
/ epidemiology
Tertiary Care Centers
Viral Load
Young Adult
Hepatitis B
Pregnancy
Tanzania
Vertical transmission
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
05 Jun 2020
05 Jun 2020
Historique:
received:
14
11
2019
accepted:
15
05
2020
entrez:
7
6
2020
pubmed:
7
6
2020
medline:
8
7
2020
Statut:
epublish
Résumé
Tanzania has a high prevalence (7.17%) of chronic hepatitis B infection. Mother to Child transmission is very common, resulting in high rate of chronic infections. Currently, there is no screening program for HBV in pregnant women. This study investigated the prevalence and risk factors for chronic HBV infection in pregnant women in a tertiary hospital in Mwanza, Tanzania. Seven hundred and forty-three women attending antenatal care and/or delivering at the Bugando Medical Centre were enrolled. All answered a questionnaire on sociodemographic and other risk factors and were tested for HBsAg using a rapid test. In HBsAg positive mothers, maternal blood and umbilical cord blood samples collected after delivery were analyzed for serological (HBsAg, HBeAg and anti-HBe) and virologic (HBV-DNA viral load and genotype) markers. All their babies were vaccinated within 24 h of delivery. The children were followed up at 3 years of age. Data was analyzed using the Mann-Whitney U-test, independent sample T-test and logistic regression. Of the 743 participants, 22 (3%) were positive for HBsAg, and 2 (9%) had detectable HBe-antigen. Low condom use was the only statistically significant risk factor for chronic HBV infection (OR = 3.514, 95%CI = 1.4-8.0). Of 14 maternal blood samples genotyped, 10 (71%) were genotype A and 4 (29%) were genotype D. HBV-DNA was detected in 21/22 samples, with a median of 241 IU/ml (range: 27.4-25.9 × 10 This cohort of pregnant women showed a lower-intermediate prevalence of HBV of 3%. In the 3 years follow-up only 1 out of 7 children showed evidence of chronic HBV infection. The child's mother with high viral load (25.9 × 10
Sections du résumé
BACKGROUND
BACKGROUND
Tanzania has a high prevalence (7.17%) of chronic hepatitis B infection. Mother to Child transmission is very common, resulting in high rate of chronic infections. Currently, there is no screening program for HBV in pregnant women. This study investigated the prevalence and risk factors for chronic HBV infection in pregnant women in a tertiary hospital in Mwanza, Tanzania.
METHODS
METHODS
Seven hundred and forty-three women attending antenatal care and/or delivering at the Bugando Medical Centre were enrolled. All answered a questionnaire on sociodemographic and other risk factors and were tested for HBsAg using a rapid test. In HBsAg positive mothers, maternal blood and umbilical cord blood samples collected after delivery were analyzed for serological (HBsAg, HBeAg and anti-HBe) and virologic (HBV-DNA viral load and genotype) markers. All their babies were vaccinated within 24 h of delivery. The children were followed up at 3 years of age. Data was analyzed using the Mann-Whitney U-test, independent sample T-test and logistic regression.
RESULTS
RESULTS
Of the 743 participants, 22 (3%) were positive for HBsAg, and 2 (9%) had detectable HBe-antigen. Low condom use was the only statistically significant risk factor for chronic HBV infection (OR = 3.514, 95%CI = 1.4-8.0). Of 14 maternal blood samples genotyped, 10 (71%) were genotype A and 4 (29%) were genotype D. HBV-DNA was detected in 21/22 samples, with a median of 241 IU/ml (range: 27.4-25.9 × 10
CONCLUSION
CONCLUSIONS
This cohort of pregnant women showed a lower-intermediate prevalence of HBV of 3%. In the 3 years follow-up only 1 out of 7 children showed evidence of chronic HBV infection. The child's mother with high viral load (25.9 × 10
Identifiants
pubmed: 32503443
doi: 10.1186/s12879-020-05096-2
pii: 10.1186/s12879-020-05096-2
pmc: PMC7275503
doi:
Substances chimiques
DNA, Viral
0
Hepatitis B Antibodies
0
Hepatitis B Surface Antigens
0
Hepatitis B e Antigens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
395Références
Lancet. 2015 Oct 17;386(10003):1546-55
pubmed: 26231459
Hepatol Res. 2007 Jul;37(s1):S9-S19
pubmed: 17627641
Clin Vaccine Immunol. 2010 Dec;17(12):1836-41
pubmed: 20943880
PLoS One. 2017 Jul 21;12(7):e0181267
pubmed: 28732085
Pan Afr Med J. 2017 Jun 22;27(Suppl 3):17
pubmed: 29296152
Mol Biol Evol. 2013 Dec;30(12):2725-9
pubmed: 24132122
Int J Med Sci. 2005;2(1):50-57
pubmed: 15968340
Lancet. 2016 Sep 10;388(10049):1081-1088
pubmed: 27394647
Iran Red Crescent Med J. 2015 Jul 22;17(7):e20598
pubmed: 26421168
BMC Infect Dis. 2017 Sep 11;17(1):618
pubmed: 28893207
J Pediatric Infect Dis Soc. 2013 Dec;2(4):320-6
pubmed: 24363930
Pan Afr Med J. 2017 Jun 22;27(Suppl 3):18
pubmed: 29296153
World J Gastroenterol. 2016 Oct 21;22(39):8720-8734
pubmed: 27818588
J Virol Methods. 2005 Jun;126(1-2):207-13
pubmed: 15847939
Int J Infect Dis. 2010 Nov;14(11):e941-53
pubmed: 20674432
Tanzan J Health Res. 2014 Jan;16(1):9-15
pubmed: 26867267
J Med Virol. 2008 Jul;80(7):1160-70
pubmed: 18461609
Lancet Glob Health. 2015 Jul;3(7):e358-9
pubmed: 26087980
J Trop Med. 2018 Jan 30;2018:4239646
pubmed: 29666656
J Gen Virol. 2017 May;98(5):1048-1057
pubmed: 28537543
Int J Gynaecol Obstet. 2018 Apr;141(1):126-132
pubmed: 29315536
N Engl J Med. 2016 Jun 16;374(24):2324-34
pubmed: 27305192
East Afr Med J. 2006 Feb;83(2):91-4
pubmed: 16708880
Dig Liver Dis. 2019 Jun;51(6):864-869
pubmed: 30528568
BMC Infect Dis. 2014 Mar 01;14:118
pubmed: 24580859
J Hepatol. 2017 Aug;67(2):370-398
pubmed: 28427875
Ann Trop Paediatr. 2010;30(2):129-36
pubmed: 20522299
BMC Pregnancy Childbirth. 2017 Apr 7;17(1):109
pubmed: 28388879
Lancet Gastroenterol Hepatol. 2017 Dec;2(12):900-909
pubmed: 29132759