The EMT Transcription Factor ZEB2 Promotes Proliferation of Primary and Metastatic Melanoma While Suppressing an Invasive, Mesenchymal-Like Phenotype.
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
15 07 2020
15 07 2020
Historique:
received:
01
08
2019
revised:
02
03
2020
accepted:
18
05
2020
pubmed:
7
6
2020
medline:
24
11
2020
entrez:
7
6
2020
Statut:
ppublish
Résumé
Epithelial-to-mesenchymal transition (EMT)-inducing transcription factors (TF) are well known for their ability to induce mesenchymal states associated with increased migratory and invasive properties. Unexpectedly, nuclear expression of the EMT-TF ZEB2 in human primary melanoma has been shown to correlate with reduced invasion. We report here that ZEB2 is required for outgrowth for primary melanomas and metastases at secondary sites. Ablation of
Identifiants
pubmed: 32503808
pii: 0008-5472.CAN-19-2373
doi: 10.1158/0008-5472.CAN-19-2373
doi:
Substances chimiques
Transcription Factors
0
Zinc Finger E-box Binding Homeobox 2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2983-2995Informations de copyright
©2020 American Association for Cancer Research.