Kirrel3-Mediated Synapse Formation Is Attenuated by Disease-Associated Missense Variants.
cell adhesion
synapse specificity
target selection
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
08 07 2020
08 07 2020
Historique:
received:
29
12
2019
revised:
24
05
2020
accepted:
26
05
2020
pubmed:
7
6
2020
medline:
27
11
2020
entrez:
7
6
2020
Statut:
ppublish
Résumé
Missense variants in Kirrel3 are repeatedly identified as risk factors for autism spectrum disorder and intellectual disability, but it has not been reported if or how these variants disrupt Kirrel3 function. Previously, we studied Kirrel3 loss of function using KO mice and showed that Kirrel3 is a synaptic adhesion molecule necessary to form one specific type of hippocampal synapse
Identifiants
pubmed: 32503885
pii: JNEUROSCI.3058-19.2020
doi: 10.1523/JNEUROSCI.3058-19.2020
pmc: PMC7343328
doi:
Substances chimiques
Kirrel3 protein, mouse
0
Membrane Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5376-5388Subventions
Organisme : NIMH NIH HHS
ID : R01 MH105426
Pays : United States
Organisme : NIMH NIH HHS
ID : R56 MH105426
Pays : United States
Informations de copyright
Copyright © 2020 the authors.
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