Complete mitogenome data for the Serbian population: the contribution to high-quality forensic databases.
Complete mitogenomes
Demographic changes
Molecular phylogeography
Serbian population
Journal
International journal of legal medicine
ISSN: 1437-1596
Titre abrégé: Int J Legal Med
Pays: Germany
ID NLM: 9101456
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
02
11
2019
accepted:
28
05
2020
pubmed:
7
6
2020
medline:
22
4
2021
entrez:
7
6
2020
Statut:
ppublish
Résumé
Mitochondrial genome (mtDNA) is a valuable resource in resolving various human forensic casework. The usage of variability of complete mtDNA genomes increases their discriminatory power to the maximum and enables ultimate resolution of distinct maternal lineages. However, their wider employment in forensic casework is nowadays limited by the lack of appropriate reference database. In order to fill in the gap in the reference data, which, considering Slavic-speaking populations, currently comprises only mitogenomes of East and West Slavs, we present mitogenome data for 226 Serbians, representatives of South Slavs from the Balkan Peninsula. We found 143 (sub)haplogroups among which West Eurasian ones were dominant. The percentage of unique haplotypes was 85%, and the random match probability was as low as 0.53%. We support previous findings on both high levels of genetic diversity in the Serbian population and patterns of genetic differentiation among this and ten studied European populations. However, our high-resolution data supported more pronounced genetic differentiation among Serbians and two Slavic populations (Russians and Poles) as well as expansion of the Serbian population after the Last Glacial Maximum and during the Migration period (fourth to ninth century A.D.), as inferred from the Bayesian skyline analysis. Phylogenetic analysis of haplotypes found in Serbians contributed towards the improvement of the worldwide mtDNA phylogeny, which is essential for the interpretation of the mtDNA casework.
Identifiants
pubmed: 32504149
doi: 10.1007/s00414-020-02324-x
pii: 10.1007/s00414-020-02324-x
doi:
Substances chimiques
DNA, Mitochondrial
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1581-1590Subventions
Organisme : Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
ID : 451-03-68/2020-14/200042
Organisme : Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja
ID : 47025
Organisme : Российский Фонд Фундаментальных Исследований (РФФИ)
ID : 14-04-00131
Organisme : Российский Фонд Фундаментальных Исследований (РФФИ)
ID : 16-34-00014
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