Cell composition and expansion strategy can reduce the beneficial effect of AKT-inhibition on functionality of CD8


Journal

Cancer immunology, immunotherapy : CII
ISSN: 1432-0851
Titre abrégé: Cancer Immunol Immunother
Pays: Germany
ID NLM: 8605732

Informations de publication

Date de publication:
Nov 2020
Historique:
received: 28 11 2019
accepted: 15 05 2020
pubmed: 7 6 2020
medline: 23 10 2020
entrez: 7 6 2020
Statut: ppublish

Résumé

AKT-inhibition is a promising approach to improve T cell therapies; however, its effect on CD4

Identifiants

pubmed: 32504246
doi: 10.1007/s00262-020-02612-w
pii: 10.1007/s00262-020-02612-w
pmc: PMC7568704
doi:

Substances chimiques

1,3-dihydro-1-(1-((4-(6-phenyl-1H-imidazo(4,5-g)quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one 0
Benzimidazoles 0
Quinoxalines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

2259-2273

Subventions

Organisme : KWF Kankerbestrijding
ID : KUN2014-6716

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Auteurs

Charlotte M Mousset (CM)

Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute of Molecular Life Sciences, Radboud university medical center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands.

Willemijn Hobo (W)

Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute of Molecular Life Sciences, Radboud university medical center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands.

Aafke de Ligt (A)

Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute of Molecular Life Sciences, Radboud university medical center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands.

Sjoerd Baardman (S)

Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute of Molecular Life Sciences, Radboud university medical center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands.

Nicolaas P M Schaap (NPM)

Department of Hematology, Radboud university medical center, Nijmegen, The Netherlands.

Joop H Jansen (JH)

Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute of Molecular Life Sciences, Radboud university medical center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands.

Anniek B van der Waart (AB)

Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute of Molecular Life Sciences, Radboud university medical center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands.

Harry Dolstra (H)

Department of Laboratory Medicine, Laboratory of Hematology, Radboud Institute of Molecular Life Sciences, Radboud university medical center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands. Harry.Dolstra@radboudumc.nl.

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