Antihyperalgesic effects of intrathecal perospirone in a rat model of neuropathic pain.
Analgesics
/ administration & dosage
Animals
Disease Models, Animal
Dose-Response Relationship, Drug
Hyperalgesia
/ drug therapy
Injections, Spinal
/ methods
Isoindoles
/ administration & dosage
Male
Neuralgia
/ drug therapy
Pain Measurement
/ drug effects
Piperazines
/ pharmacology
Pyridines
/ pharmacology
Rats
Rats, Sprague-Dawley
Receptor, Serotonin, 5-HT1A
/ metabolism
Rotarod Performance Test
Serotonin 5-HT1 Receptor Antagonists
/ pharmacology
Signal Transduction
/ drug effects
Thiazoles
/ administration & dosage
Atypical antipsychotic
CCI model
Dopaminergic transmission
Serotonergic transmission
Spinal cord
Journal
Pharmacology, biochemistry, and behavior
ISSN: 1873-5177
Titre abrégé: Pharmacol Biochem Behav
Pays: United States
ID NLM: 0367050
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
16
12
2019
revised:
15
03
2020
accepted:
01
06
2020
pubmed:
7
6
2020
medline:
9
2
2021
entrez:
7
6
2020
Statut:
ppublish
Résumé
The descending serotonergic pathway, from the brainstem to spinal cord, modulates various aspects of pain processing. The spinal 5-hydroxytryptamine (5-HT)
Identifiants
pubmed: 32504731
pii: S0091-3057(19)30636-7
doi: 10.1016/j.pbb.2020.172964
pii:
doi:
Substances chimiques
Analgesics
0
Isoindoles
0
Piperazines
0
Pyridines
0
Serotonin 5-HT1 Receptor Antagonists
0
Thiazoles
0
Receptor, Serotonin, 5-HT1A
112692-38-3
N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide
71IH826FEG
perospirone
N303OK87DT
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
172964Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest None.