Pluripotent stem cell-derived retinal organoids for disease modeling and development of therapies.
neural differentiation
retina
retinal photoreceptors
somatic stem cells
Journal
Stem cells (Dayton, Ohio)
ISSN: 1549-4918
Titre abrégé: Stem Cells
Pays: England
ID NLM: 9304532
Informations de publication
Date de publication:
01 10 2020
01 10 2020
Historique:
received:
17
04
2020
revised:
16
05
2020
accepted:
17
05
2020
pubmed:
9
6
2020
medline:
7
7
2021
entrez:
8
6
2020
Statut:
ppublish
Résumé
Retinal diseases constitute a genetically and phenotypically diverse group of clinical conditions leading to vision impairment or blindness with limited treatment options. Advances in reprogramming of somatic cells to induced pluripotent stem cells and generation of three-dimensional organoids resembling the native retina offer promising tools to interrogate disease mechanisms and evaluate potential therapies for currently incurable retinal neurodegeneration. Next-generation sequencing, single-cell analysis, advanced electrophysiology, and high-throughput screening approaches are expected to greatly expand the utility of stem cell-derived retinal cells and organoids for developing personalized treatments. In this review, we discuss the current status and future potential of combining retinal organoids as human models with recent technologies to advance the development of gene, cell, and drug therapies for retinopathies.
Identifiants
pubmed: 32506758
doi: 10.1002/stem.3239
pmc: PMC7586922
doi:
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1206-1215Subventions
Organisme : Intramural NIH HHS
ID : ZIA EY000450
Pays : United States
Organisme : NEI NIH HHS
ID : ZIAEY000546
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA EY000474
Pays : United States
Organisme : NEI NIH HHS
ID : ZIAEY000474
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA EY000546
Pays : United States
Organisme : NEI NIH HHS
ID : ZIAEY000450
Pays : United States
Informations de copyright
©2020 The Authors. Stem Cells published by Wiley Periodicals LLC on behalf of AlphaMed Press 2020.
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