Tuberculosis transmission across three states: The story of a solid organ donor born in an endemic country, 2018.
Allografts
/ microbiology
Antitubercular Agents
/ therapeutic use
Diagnostic Tests, Routine
/ methods
Female
Humans
Incidence
Male
Mycobacterium tuberculosis
/ genetics
Organ Transplantation
/ adverse effects
Risk Factors
Tissue Donors
Tomography, X-Ray Computed
/ methods
Transplant Recipients
Treatment Outcome
Tuberculosis
/ diagnosis
Whole Genome Sequencing
/ methods
donor-derived infections
solid organ transplantation
tuberculosis
Journal
Transplant infectious disease : an official journal of the Transplantation Society
ISSN: 1399-3062
Titre abrégé: Transpl Infect Dis
Pays: Denmark
ID NLM: 100883688
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
16
01
2020
revised:
11
05
2020
accepted:
24
05
2020
pubmed:
9
6
2020
medline:
4
6
2021
entrez:
9
6
2020
Statut:
ppublish
Résumé
Transmission of tuberculosis (TB) from a deceased solid organ donor to recipients can result in severe morbidity and mortality. In 2018, four solid organ transplant recipients residing in three states but sharing a common organ donor were diagnosed with TB disease. Two recipients were hospitalized and none died. The organ donor was born in a country with a high incidence of TB and experienced 8 weeks of headache and fever prior to death, but was not tested for TB during multiple hospitalizations or prior to organ procurement. TB isolates of two organ recipients and a close contact of the donor had identical TB genotypes and closely related whole-genome sequencing results. Donors with risk factors for TB, in particular birth or residence in countries with a higher TB incidence, should be carefully evaluated for TB.
Identifiants
pubmed: 32510808
doi: 10.1111/tid.13357
pmc: PMC7879577
mid: NIHMS1669700
doi:
Substances chimiques
Antitubercular Agents
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13357Subventions
Organisme : Intramural CDC HHS
ID : CC999999
Pays : United States
Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
Clin Transplant. 2018 Jun;32(6):e13259
pubmed: 29656530
Transpl Infect Dis. 2018 Oct;20(5):e12971
pubmed: 30055041
Clin Microbiol Infect. 2014 Sep;20 Suppl 7:89-101
pubmed: 24707957
Clin Infect Dis. 2016 Oct 1;63(7):e147-e195
pubmed: 27516382
Am J Respir Crit Care Med. 2012 Apr 1;185(7):779-84
pubmed: 22161161
Am J Transplant. 2011 Jun;11(6):1123-30
pubmed: 21443676
J Hosp Med. 2016 Jun;11(6):413-7
pubmed: 27042950
Infect Genet Evol. 2012 Jun;12(4):782-8
pubmed: 22044522
Clin Infect Dis. 2017 Jan 15;64(2):e1-e33
pubmed: 27932390
Am J Transplant. 2012 Sep;12(9):2288-300
pubmed: 22883346