Inhibitory effects of organophosphate esters on carboxylesterase activity of rat liver microsomes.

Animals Carboxylesterase / antagonists & inhibitors Enzyme Assays Enzyme Inhibitors / chemistry Kinetics Microsomes, Liver / drug effects Molecular Structure Organophosphates / chemistry Rats Structure-Activity Relationship
Carboxylesterase Inhibition Organophosphate esters Rat liver microsomes

Journal

Chemico-biological interactions
ISSN: 1872-7786
Titre abrégé: Chem Biol Interact
Pays: Ireland
ID NLM: 0227276

Informations de publication

Date de publication:
25 Aug 2020
Historique:
received: 11 04 2019
revised: 25 05 2020
accepted: 28 05 2020
pubmed: 9 6 2020
medline: 1 9 2020
entrez: 9 6 2020
Statut: ppublish

Résumé

We investigated the inhibitory effects of 13 organophosphate esters (OPEs) and hydrolytic metabolites on the carboxylesterase activity of rat liver microsomes in vitro in order to examine whether there might be a potential impact on human health, and to elucidate the structure activity relationship. Among the test compounds, 2-ethylhexyl diphenyl phosphate (EDPhP) was the most potent inhibitor of carboxylesterase activity, as measured in terms of 4-nitrophenol acetate hydrolase activity, followed by tri-m-cresyl phosphate (TmCP), cresyl diphenyl phosphate (CDPhP) and triphenyl phosphate (TPhP). The IC

Identifiants

DOI: 10.1016/j.cbi.2020.109148 PMID: 32511959
pubmed: 32511959
pii: S0009-2797(19)30553-8
doi: 10.1016/j.cbi.2020.109148
pii:
doi:

Substances chimiques

Enzyme Inhibitors 0
Organophosphates 0
Carboxylesterase EC 3.1.1.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

109148

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Yukie Tsugoshi (Y)

Nihon Pharmaceutical University, Komuro 10281, Inamachi, Kitaadachi-gun, Saitama, 362-0806, Japan.

Yoko Watanabe (Y)

Nihon Pharmaceutical University, Komuro 10281, Inamachi, Kitaadachi-gun, Saitama, 362-0806, Japan.

Yuka Tanikawa (Y)

Nihon Pharmaceutical University, Komuro 10281, Inamachi, Kitaadachi-gun, Saitama, 362-0806, Japan.

Chika Inoue (C)

Nihon Pharmaceutical University, Komuro 10281, Inamachi, Kitaadachi-gun, Saitama, 362-0806, Japan.

Kazumi Sugihara (K)

Faculty of Pharmaceutical Science, Hiroshima International University, Koshingai 5-1-1, Kure, Hiroshima, 737-0112, Japan.

Hiroyuki Kojima (H)

School of Pharmaceutical Sciences, Health Sciences University of Hokkaido, 1757 Kanazawa, Ishikari-Tobetsu, Hokkaido, 061-0293, Japan.

Shigeyuki Kitamura (S)

Nihon Pharmaceutical University, Komuro 10281, Inamachi, Kitaadachi-gun, Saitama, 362-0806, Japan. Electronic address: kitamura@nichiyaku.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Inhibitory effects of organophosphate esters...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Carboxylesterase › Inhibitory effects of organophosphate esters...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Dosages enzymatiques › Inhibitory effects of organophosphate esters...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibitory effects of organophosphate esters...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Inhibitory effects of organophosphate esters...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Microsomes › Microsomes du foie › Inhibitory effects of organophosphate esters...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Inhibitory effects of organophosphate esters...
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Organophosphates › Inhibitory effects of organophosphate esters...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Inhibitory effects of organophosphate esters...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Inhibitory effects of organophosphate esters...