The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer.

Animals Antineoplastic Agents / therapeutic use Cells, Cultured Disease Models, Animal Genes, Tumor Suppressor Humans Mice, Transgenic Phosphatidylinositols / metabolism Phosphoric Monoester Hydrolases / genetics Protein Kinase Inhibitors / therapeutic use Receptor Protein-Tyrosine Kinases / genetics Signal Transduction Triple Negative Breast Neoplasms / drug therapy

Journal

Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693

Informations de publication

Date de publication:
08 2020
Historique:
received: 23 10 2019
revised: 22 04 2020
accepted: 02 06 2020
pubmed: 10 6 2020
medline: 30 11 2021
entrez: 10 6 2020
Statut: ppublish

Résumé

Inactivation of the tumor suppressor lipid phosphatase INPP4B is common in triple-negative breast cancer (TNBC). We generated a genetically engineered TNBC mouse model deficient in

Identifiants

DOI: 10.1158/2159-8290.CD-19-1262 PMID: 32513774 PMC: PMC7415683
pubmed: 32513774
pii: 2159-8290.CD-19-1262
doi: 10.1158/2159-8290.CD-19-1262
pmc: PMC7415683
mid: NIHMS1602226
doi:

Substances chimiques

Antineoplastic Agents 0
Phosphatidylinositols 0
Protein Kinase Inhibitors 0
phosphoinositide-3,4-bisphosphate 0
Receptor Protein-Tyrosine Kinases EC 2.7.10.1
Phosphoric Monoester Hydrolases EC 3.1.3.2
phosphatidylinositol-3,4-bisphosphate 4-phosphatase EC 3.1.3.66

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1226-1239

Subventions

Organisme : NCI NIH HHS
ID : F31 CA213460
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA210184
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA197588
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA177910
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA200671
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA226776
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA253097
Pays : United States

Informations de copyright

©2020 American Association for Cancer Research.

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Auteurs

Hui Liu (H)

Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. atoker@bidmc.harvard.edu LCantley@med.cornell.edu hliu5@bidmc.harvard.edu.

Marcia N Paddock (MN)

Meyer Cancer Center, Weill Cornell Medicine, New York, New York.

Haibin Wang (H)

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.

Charles J Murphy (CJ)

Meyer Cancer Center, Weill Cornell Medicine, New York, New York.
Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.

Renee C Geck (RC)

Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
ORCID: 0000-0001-7812-7675

Adrija J Navarro (AJ)

Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Gerburg M Wulf (GM)

Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.

Olivier Elemento (O)

Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, New York.

Volker Haucke (V)

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
ORCID: 0000-0003-3119-6993

Lewis C Cantley (LC)

Meyer Cancer Center, Weill Cornell Medicine, New York, New York. atoker@bidmc.harvard.edu LCantley@med.cornell.edu hliu5@bidmc.harvard.edu.
ORCID: 0000-0002-1298-7653

Alex Toker (A)

Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. atoker@bidmc.harvard.edu LCantley@med.cornell.edu hliu5@bidmc.harvard.edu.
Ludwig Center at Harvard, Boston, Massachusetts.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The INPP4B Tumor Suppressor Modulates EGFR...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › The INPP4B Tumor Suppressor Modulates EGFR...
questionsmedicales.fr › Cellules › Cellules cultivées › The INPP4B Tumor Suppressor Modulates EGFR...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › The INPP4B Tumor Suppressor Modulates EGFR...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes suppresseurs de tumeur › The INPP4B Tumor Suppressor Modulates EGFR...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The INPP4B Tumor Suppressor Modulates EGFR...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › The INPP4B Tumor Suppressor Modulates EGFR...
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Glycérophospholipides › Phosphatidyl inositols › The INPP4B Tumor Suppressor Modulates EGFR...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Phosphoric monoester hydrolases › The INPP4B Tumor Suppressor Modulates EGFR...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéines kinases › The INPP4B Tumor Suppressor Modulates EGFR...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs à activité tyrosine kinase › The INPP4B Tumor Suppressor Modulates EGFR...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › The INPP4B Tumor Suppressor Modulates EGFR...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Tumeurs du sein triple-négatives › The INPP4B Tumor Suppressor Modulates EGFR...