Incomplete glycosylation during prion infection unmasks a prion protein epitope that facilitates prion detection and strain discrimination.

Animals Antibodies, Monoclonal, Murine-Derived / chemistry Cell Line Epitopes / chemistry Glycosylation PrPC Proteins / chemistry Rabbits
Creutzfeldt-Jakob disease N-linked glycosylation PRC7 bovine spongiform encephalopathy chronic wasting disease monoclonal antibody neurodegeneration prion prion disease prion strains prions protein misfolding

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
24 07 2020
Historique:
received: 24 01 2020
revised: 31 05 2020
pubmed: 10 6 2020
medline: 14 1 2021
entrez: 10 6 2020
Statut: ppublish

Résumé

The causative factors underlying conformational conversion of cellular prion protein (PrP

Identifiants

DOI: 10.1074/jbc.RA120.012796 PMID: 32513872 PMC: PMC7383396
pubmed: 32513872
pii: S0021-9258(17)50147-7
doi: 10.1074/jbc.RA120.012796
pmc: PMC7383396
doi:

Substances chimiques

Antibodies, Monoclonal, Murine-Derived 0
Epitopes 0
PrPC Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

10420-10433

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS121682
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS103763
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS040334
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS109376
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI077774
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS052609
Pays : United States

Informations de copyright

© 2020 Kang et al.

Déclaration de conflit d'intérêts

Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.

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Auteurs

Hae-Eun Kang (HE)

Prion Research Center (PRC), the Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado.

Jifeng Bian (J)

Prion Research Center (PRC), the Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado.
ORCID: 0000-0001-6838-9938

Sarah J Kane (SJ)

Prion Research Center (PRC), the Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado.
ORCID: 0000-0002-6072-5682

Sehun Kim (S)

Prion Research Center (PRC), the Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado.

Vanessa Selwyn (V)

Prion Research Center (PRC), the Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado.
Program in Cell and Molecular Biology, Colorado State University, Fort Collins, Colorado.

Jenna Crowell (J)

Prion Research Center (PRC), the Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado.

Jason C Bartz (JC)

Department of Medical Microbiology and Immunology, Creighton University, Omaha, Nebraska.
ORCID: 0000-0003-4081-7886

Glenn C Telling (GC)

Prion Research Center (PRC), the Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado glenn.telling@colostate.edu.
Program in Cell and Molecular Biology, Colorado State University, Fort Collins, Colorado.
ORCID: 0000-0002-6294-1805

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Incomplete glycosylation during prion...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Anticorps monoclonaux d'origine murine › Incomplete glycosylation during prion...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Incomplete glycosylation during prion...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Épitopes › Incomplete glycosylation during prion...
questionsmedicales.fr › Métabolisme › Métabolisme glucidique › Glycosylation › Incomplete glycosylation during prion...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Prions › Protéines prion › Protéines PrPC › Incomplete glycosylation during prion...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Lagomorpha › Lapins › Incomplete glycosylation during prion...