Ultrasonographic assessment of the effect of metoclopramide, erythromycin, and exenatide on solid-phase gastric emptying in healthy cats.
Animals
Cats
Cross-Over Studies
Erythromycin
/ pharmacology
Exenatide
/ pharmacology
Female
Gastric Emptying
/ drug effects
Gastrointestinal Agents
/ pharmacology
Gastrointestinal Motility
/ drug effects
Male
Metoclopramide
/ pharmacology
Prospective Studies
Stomach
/ diagnostic imaging
Ultrasonography
/ veterinary
antral area
gastrointestinal motility disorder
motility index
ultrasound
Journal
Journal of veterinary internal medicine
ISSN: 1939-1676
Titre abrégé: J Vet Intern Med
Pays: United States
ID NLM: 8708660
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
21
01
2020
revised:
08
04
2020
accepted:
10
04
2020
pubmed:
10
6
2020
medline:
11
3
2021
entrez:
10
6
2020
Statut:
ppublish
Résumé
Available data on the effect of gastrointestinal motility-modifying drugs in cats are limited. Most recommendations for drug usage and dosage are based on collective clinical experience. To assess the effects of metoclopramide, erythromycin, and exenatide on gastric emptying (GE) and gastric motility in comparison to placebo. We hypothesized that metoclopramide and erythromycin would have prokinetic gastric effects, whereas exenatide would prolong GE times and decrease the motility index (MI) of antral contractions. Eight healthy domestic shorthair cats. Each cat had 4 separate ultrasonographic assessments. In a prospective, randomized, double-blind, 4-way crossover design, cats received placebo, metoclopramide, erythromycin, or exenatide for 2 days followed by a minimum 5-day washout period. Ultrasonographic GE times and MI were compared to placebo. When compared to placebo, the rate of GE was significantly faster after administration of metoclopramide and erythromycin. Significant differences were found at all fractions of GE after administration of erythromycin and all but 1 fraction after metoclopramide when compared to placebo. The rate of GE in the first half of the GE curve was significantly slower after exenatide administration. The total area under the Ml curve was significantly larger after administration of metoclopramide and erythromycin than after placebo. Metoclopramide and erythromycin shorten GE times and increase the MI of antral contractions, thus having a prokinetic effect in the stomach of healthy cats, whereas exenatide causes an initial delay in GE.
Sections du résumé
BACKGROUND
BACKGROUND
Available data on the effect of gastrointestinal motility-modifying drugs in cats are limited. Most recommendations for drug usage and dosage are based on collective clinical experience.
OBJECTIVES
OBJECTIVE
To assess the effects of metoclopramide, erythromycin, and exenatide on gastric emptying (GE) and gastric motility in comparison to placebo. We hypothesized that metoclopramide and erythromycin would have prokinetic gastric effects, whereas exenatide would prolong GE times and decrease the motility index (MI) of antral contractions.
ANIMALS
METHODS
Eight healthy domestic shorthair cats.
METHODS
METHODS
Each cat had 4 separate ultrasonographic assessments. In a prospective, randomized, double-blind, 4-way crossover design, cats received placebo, metoclopramide, erythromycin, or exenatide for 2 days followed by a minimum 5-day washout period. Ultrasonographic GE times and MI were compared to placebo.
RESULTS
RESULTS
When compared to placebo, the rate of GE was significantly faster after administration of metoclopramide and erythromycin. Significant differences were found at all fractions of GE after administration of erythromycin and all but 1 fraction after metoclopramide when compared to placebo. The rate of GE in the first half of the GE curve was significantly slower after exenatide administration. The total area under the Ml curve was significantly larger after administration of metoclopramide and erythromycin than after placebo.
CONCLUSIONS AND CLINICAL IMPORTANCE
CONCLUSIONS
Metoclopramide and erythromycin shorten GE times and increase the MI of antral contractions, thus having a prokinetic effect in the stomach of healthy cats, whereas exenatide causes an initial delay in GE.
Identifiants
pubmed: 32515089
doi: 10.1111/jvim.15787
pmc: PMC7379023
doi:
Substances chimiques
Gastrointestinal Agents
0
Erythromycin
63937KV33D
Exenatide
9P1872D4OL
Metoclopramide
L4YEB44I46
Types de publication
Clinical Trial, Veterinary
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1440-1446Informations de copyright
© 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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