The protective effect of
Akkermansia
/ growth & development
Animals
Aspirin
/ adverse effects
Bifidobacterium bifidum
/ growth & development
Cytokines
/ metabolism
Dietary Sugars
/ administration & dosage
Goblet Cells
/ metabolism
Humans
Intestinal Mucosa
/ microbiology
Intestine, Small
/ drug effects
Jejunum
/ drug effects
Male
Mice
Mice, Inbred C57BL
Mucus
/ metabolism
Omeprazole
/ adverse effects
Permeability
Probiotics
Proton Pump Inhibitors
/ adverse effects
T-Lymphocytes, Regulatory
/ immunology
Akkermansia muciniphila
Bifidobacterium bifidum G9-1
Proton pump inhibitor
aspirin
intestinal injury
Journal
Gut microbes
ISSN: 1949-0984
Titre abrégé: Gut Microbes
Pays: United States
ID NLM: 101495343
Informations de publication
Date de publication:
02 09 2020
02 09 2020
Historique:
pubmed:
10
6
2020
medline:
29
6
2021
entrez:
10
6
2020
Statut:
ppublish
Résumé
Proton pump inhibitors (PPIs) can alleviate upper gastrointestinal injury but paradoxically exacerbate aspirin (ASA)-induced small intestine injury. In this study, our goal was to simulate this exacerbation by developing an appropriate animal model, which may help in establishing treatments.
Sections du résumé
BACKGROUND
Proton pump inhibitors (PPIs) can alleviate upper gastrointestinal injury but paradoxically exacerbate aspirin (ASA)-induced small intestine injury. In this study, our goal was to simulate this exacerbation by developing an appropriate animal model, which may help in establishing treatments.
Identifiants
pubmed: 32515658
doi: 10.1080/19490976.2020.1758290
pmc: PMC7527075
doi:
Substances chimiques
Cytokines
0
Dietary Sugars
0
Proton Pump Inhibitors
0
Omeprazole
KG60484QX9
Aspirin
R16CO5Y76E
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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