Fragment Screening Hit Draws Attention to a Novel Transient Pocket Adjacent to the Recognition Site of the tRNA-Modifying Enzyme TGT.

Benzimidazoles / pharmacology Binding Sites Drug Design Drug Evaluation, Preclinical Ligands Models, Molecular Pentosyltransferases / chemistry Protein Conformation Shigella / enzymology

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
09 07 2020
Historique:
pubmed: 10 6 2020
medline: 18 11 2020
entrez: 10 6 2020
Statut: ppublish

Résumé

Fragment-based lead discovery was applied to tRNA-guanine transglycosylase, an enzyme modifying post-transcriptionally tRNAs in

Identifiants

DOI: 10.1021/acs.jmedchem.0c00115 PMID: 32515955
pubmed: 32515955
doi: 10.1021/acs.jmedchem.0c00115
doi:

Substances chimiques

Benzimidazoles 0
Ligands 0
benzimidazole E24GX49LD8
Pentosyltransferases EC 2.4.2.-
queuine tRNA-ribosyltransferase EC 2.4.2.29

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6802-6820

Auteurs

Engi Hassaan (E)

Institute of Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 6, 35032 Marburg, Germany.
ORCID: 0000-0001-7393-7687

Christoph Hohn (C)

Laboratorium für Organische Chemie, ETH Zurich, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland.
ORCID: 0000-0003-2406-7683

Frederik R Ehrmann (FR)

Institute of Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 6, 35032 Marburg, Germany.

F Wieland Goetzke (FW)

Laboratorium für Organische Chemie, ETH Zurich, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland.
ORCID: 0000-0002-8688-5609

Levon Movsisyan (L)

Laboratorium für Organische Chemie, ETH Zurich, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland.

Tobias Hüfner-Wulsdorf (T)

Institute of Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 6, 35032 Marburg, Germany.

Maurice Sebastiani (M)

Institute of Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 6, 35032 Marburg, Germany.

Adrian Härtsch (A)

Laboratorium für Organische Chemie, ETH Zurich, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland.

Klaus Reuter (K)

Institute of Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 6, 35032 Marburg, Germany.
ORCID: 0000-0003-3673-7971

François Diederich (F)

Laboratorium für Organische Chemie, ETH Zurich, Vladimir-Prelog-Weg 3, 8093 Zurich, Switzerland.
ORCID: 0000-0003-1947-6327

Gerhard Klebe (G)

Institute of Pharmaceutical Chemistry, University of Marburg, Marbacher Weg 6, 35032 Marburg, Germany.
ORCID: 0000-0002-4913-390X

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzimidazoles › Fragment Screening Hit Draws Attention to a...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Fragment Screening Hit Draws Attention to a...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Conception de médicament › Fragment Screening Hit Draws Attention to a...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Fragment Screening Hit Draws Attention to a...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Fragment Screening Hit Draws Attention to a...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Fragment Screening Hit Draws Attention to a...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Pentosyltransferases › Fragment Screening Hit Draws Attention to a...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Fragment Screening Hit Draws Attention to a...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Shigella › Fragment Screening Hit Draws Attention to a...