Paget's Disease of Bone and Cardiovascular Risk: A Pilot Study.
Paget's disease of bone
cardiovascular risk
carotid intima-media thickness
disorder bone.
pulse wave velocity
Journal
Current vascular pharmacology
ISSN: 1875-6212
Titre abrégé: Curr Vasc Pharmacol
Pays: United Arab Emirates
ID NLM: 101157208
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
02
2020
revised:
06
05
2020
accepted:
07
05
2020
pubmed:
10
6
2020
medline:
6
1
2022
entrez:
10
6
2020
Statut:
ppublish
Résumé
The association between Paget's disease of bone (PDB) and increased cardiovascular (CV) risk has been suggested, but the literature is conflicting. Our study aimed to evaluate two markers of CV risk, namely, common carotid artery intimamedia thickness (cIMT) and the aortic pulse wave velocity (PWV) in patients with PDB. We enrolled 12 patients with PDB and 58 control subjects, matched for age. The diagnosis of PDB was based on clinical, radiological and biochemical parameters. Patients with PDB showed higher PWV values than the controls, whereas cIMT was slightly but not significantly increased. These findings, although limited by the small study population, represent an original observation that deserves further study. The higher arterial stiffness in PDB could be related to the increased bone turnover or the high levels of oxidative stress that characterize this population.
Sections du résumé
BACKGROUND
The association between Paget's disease of bone (PDB) and increased cardiovascular (CV) risk has been suggested, but the literature is conflicting.
OBJECTIVE
Our study aimed to evaluate two markers of CV risk, namely, common carotid artery intimamedia thickness (cIMT) and the aortic pulse wave velocity (PWV) in patients with PDB.
METHODS
We enrolled 12 patients with PDB and 58 control subjects, matched for age. The diagnosis of PDB was based on clinical, radiological and biochemical parameters.
RESULTS
Patients with PDB showed higher PWV values than the controls, whereas cIMT was slightly but not significantly increased.
CONCLUSION
These findings, although limited by the small study population, represent an original observation that deserves further study. The higher arterial stiffness in PDB could be related to the increased bone turnover or the high levels of oxidative stress that characterize this population.
Identifiants
pubmed: 32516100
pii: CVP-EPUB-107221
doi: 10.2174/1389450121666200609151555
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
423-428Informations de copyright
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