A Systematic Review of the Self-Medication Hypothesis in the Context of Posttraumatic Stress Disorder and Comorbid Problematic Alcohol Use.
Journal
Journal of traumatic stress
ISSN: 1573-6598
Titre abrégé: J Trauma Stress
Pays: United States
ID NLM: 8809259
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
01
07
2019
revised:
10
10
2019
accepted:
10
12
2019
pubmed:
10
6
2020
medline:
31
8
2021
entrez:
10
6
2020
Statut:
ppublish
Résumé
Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) commonly co-occur and are associated with many negative public health outcomes. There are several etiological models that explain the overlap between PTSD and AUD, including shared genetic risk and phenotypic causality, but the predominant model of etiologic association is the drinking-to-cope self-medication model. Although the self-medication model is conceptually appealing and has been widely accepted within the literature examining alcohol use and anxiety (e.g., PTSD) phenotypes, the findings are inconsistent and there is a lack of rigorous empirical evidence in support of this model. This review, which was, to our knowledge, the first systematic review of the self-medication model in relation to PTSD to date, aimed to synthesize the current literature on the association between PTSD and problematic alcohol use within the context of the self-medication model. In total, 24 studies met the inclusion criteria for the review and assessed the self-medication hypothesis using a variety of measurement instruments and data analytic approaches, such as mediation, moderation, and regression. Overall, the included studies provide evidence for the self-medication hypothesis but are limited in rigor due to methodological limitations. These limitations, which include issues with the operationalization (or lack thereof) of trauma-related drinking to cope, are discussed, and directions for future research are presented.
Identifiants
pubmed: 32516487
doi: 10.1002/jts.22521
pmc: PMC7572615
mid: NIHMS1580361
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
699-708Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA020179
Pays : United States
Organisme : NIAAA NIH HHS
ID : F31 AA027703
Pays : United States
Organisme : NIMHD NIH HHS
ID : P60 MD002256
Pays : United States
Organisme : NIAAA NIH HHS
ID : K02 AA023239
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH101518
Pays : United States
Organisme : NIAAA NIH HHS
ID : F31 AA025820
Pays : United States
Informations de copyright
© 2020 International Society for Traumatic Stress Studies.
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